用小剂量布比卡因进行单次脊髓麻醉。

Regional anesthesia Pub Date : 1997-11-01
M Gentili, H Senlis, P Houssel, B Monnier, F Bonnet
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引用次数: 0

摘要

背景和目的:脊髓利多卡因的潜在风险引起了人们对另一种局部麻醉溶液的兴趣。因此,在一项双盲随机前瞻性研究中评估了小剂量脊髓布比卡因给药后的麻醉阻滞特征。方法:90例计划进行下肢隐静脉剥离的患者随机接受含有4、6或8 mg布比卡因的4 ml高压溶液在蛛网膜下腔。定期评估感觉和运动阻滞及血流动力学变化。患者也被询问是否有短暂的神经根刺激症状。结果:感觉阻滞的平均持续时间随着剂量的增加而增加(L2持续时间:4、6、8 mg组分别为56 +/- 27,71 +/- 29,79 +/- 25min, P < 0.05)。运动阻滞也是剂量依赖性的。3级运动阻滞的发生率从0%增加到21%和53%。无患者出现短暂性神经根刺激症状。在整个研究过程中,动脉压和心率保持稳定。结论:高压压布比卡因6- 8mg在短时间外科手术中可替代脊柱利多卡因。
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Single-shot spinal anesthesia with small doses of bupivacaine.

Background and objectives: The potential risks of spinal lidocaine have generated interest in an alternative local anesthetic solution. Features of anesthetic block were therefore assessed in a double-blind randomized prospective study following administration of spinal bupivacaine in small doses.

Methods: Ninety patients scheduled for lower limb saphenous vein stripping were randomized to receive a 4-mL hyperbaric solution containing 4, 6, or 8 mg bupivacaine in the subarachnoid space. Sensory and motor block and hemodynamic changes were assessed at regular intervals. Patients were also questioned regarding transient radicular irritation symptoms.

Results: The mean duration of sensory block increased with increasing dose (duration at L2: 56 +/- 27, 71 +/- 29, 79 +/- 25 minutes in groups 4, 6, and 8 mg, respectively, P < .05). Motor block was also dose dependent. The incidence of grade 3 motor block increased from 0%, to 21%, and to 53%. No patient had symptoms of transient radicular irritation. Arterial pressure and heart rate were stable throughout the study.

Conclusion: Hyperbaric bupivacaine 6-8 mg provides a suitable alternative to spinal lidocaine for surgical procedures of short duration.

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