炎性细胞因子在抗原特异性CD4+ t细胞的生产性活化中的作用。

Agents and actions. Supplements Pub Date : 1998-01-01 DOI:10.1007/978-3-0348-8857-8_5

K A Pape, M K Jenkins

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引用次数: 5

摘要

研究了免疫佐剂的作用机制，使用了一种系统，该系统可以直接监测抗原给药后过继转移CD4+ t细胞受体的转基因t细胞的行为。这些研究表明，佐剂诱导的炎症细胞因子通过增强抗原激活的CD4+ t细胞的克隆扩增、持续和分化来促进免疫。

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A role for inflammatory cytokines in the productive activation of antigen-specific CD4+ T-cells.

The mechanisms of action of immunological adjuvants were studied using a system in which the behavior of adoptively transferred CD4+ T-cell receptor transgenic T-cells could be directly monitored following antigen administration. These studies revealed that adjuvant-induced inflammatory cytokines promote immunity by enhancing the clonal expansion, persistence and differentiation of antigen-activated CD4+ T-cells.

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Agents and actions. Supplements

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