草畜(Thryonomys swinderianus)炎症标志物的进化:与兔(Oryctolagus cuuniculus)和大鼠(Rattus norvegicus)的比较

H. Ahissou , T. Lebreton de Vonne , F. Esnard , H. Mouray
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引用次数: 0

摘要

注射松节油可引起割草动物的炎症反应。采用免疫比浊法观察大鼠血浆接触珠蛋白、纤维蛋白原、α2巨球蛋白和免疫球蛋白G的变化,持续23 d。结果与大鼠和家兔进行了比较。结果表明:(a)与大鼠和家兔相比,割草鼠的炎症反应延迟;(b)与大鼠和家兔相比,触珠蛋白浓度的增加幅度较小;(c)尽管草牛血液具有高凝性,但其纤维蛋白原浓度非常低;(d)切草者血浆α2-巨球蛋白的变化幅度与兔α1巨球蛋白的变化幅度相当,且恢复到初始浓度的速度较慢;(e)纤维蛋白原和触珠蛋白是监测割草炎症的适宜指标。
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Evolution of grass-cutter (Thryonomys swinderianus) inflammation markers: Comparison with rabbit (Oryctolagus cuniculus) and rat (Rattus norvegicus)

An inflammatory reaction was induced in grass-cutters (Thryonomys swinderianus) by injecting turpentine. The changes in the plasma haptoglobin, fibrinogen, α2 macroglobulin and immunoglobulin G was followed for 23 days by immunonephelometry. The results were compared to rat and rabbit. The showed that (a) the inflammatory reaction is delayed in the grass-cutter compared to rats and rabbits; (b) the concentration of haptoglobin increases less than in rat and rabbit; (c) the fibrinogen concentration is very low in the grass-cutter, despite hypercoagulability of blood; (d) the changes in the plasma α2-macroglobulin in the grass-cutter seems to be comparable to that of rabbit α1 macroglobulin in amplitude and in its slow return to the initial concentration; and (e) fibrinogen and haptoglobin are suitable markers for grass-cutter inflammation monitoring.

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