鱼肠中的一氧化氮

Catharina Olsson, Susanne Holmgren
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引用次数: 32

摘要

一氧化氮合酶阳性的神经细胞在大多数脊椎动物和一些无脊椎动物中都有发现,这表明这种酶的早期进化起源及其作为神经递质的功能。鱼类肠道中一氧化氮的总体分布和抑制作用与其他脊椎动物的研究结果一致,但物种之间的细节可能有所不同,这表明功能存在差异。与血管活性肠多肽(VIP)/垂体腺苷酸环化酶激活多肽(PACAP)共存表明在鱼类中与哺乳动物一样具有共同功能,但这还有待证实。
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Nitric oxide in the fish gut

Nitric oxide synthase-positive nerve cells have been found in most vertebrate classes and also some invertebrates, indicating an early evolutionary origin for the enzyme and its function as a neurotransmitter. The general distribution and inhibitory effect on motility of nitric oxide in the fish gut agrees well with studies from other vertebrates, but details may vary between species, suggesting variations in function. The coexistence with vasoactive intestinal polypeptide (VIP)/pituitary adenylate cyclase-activating polypeptide (PACAP) suggests a co-function in fish as in mammals, but this remains to be confirmed.

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