用事件相关脑电位和颈动脉内阿巴比妥试验研究健康人与颞叶癫痫患者的语言相关半球不对称

W Gerschlager, W Lalouschek, J Lehrner, C Baumgartner, G Lindinger, W Lang
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引用次数: 25

摘要

目前正在尝试用一种功能性脑成像方法来取代WADA测试,用于手术前半球语言能力的评估。最近的PET和fMRI研究使用动词生成、语义监测或单词的语义(“深度”)编码等言语认知任务显示,额外侧皮层的激活不对称。在之前的ERP研究中,受试者被要求指出可发音的非单词和抽象几何图形是第一次出现(“新项目”)还是之前出现过(“旧项目”)。本研究的小组分析显示了显著的材料特异性半球不对称,在记录语言材料的左半球后半部分(CP5/6)的erp更负向,而在记录空间材料的右半球(P7/8)的erp更负向。本研究的目的是在个体健康受试者和经wada检测的中颞叶(MTL)癫痫患者中统计检验ERP侧化效应。所有受试者在CP5/6和P7/8电极对中分别检测带有言语材料的ERP偏侧和带有图形的ERP偏侧。单次试验的统计分析表明,24名受试者中有20人在刺激开始后100 - 200毫秒或随后的时间点(200 - 300毫秒)内,与CP6相比,CP5中有言语材料的erp开始变得更负向。在一个被试中,邻近的电极对P7/P8而非CP5/6表现出言语材料相关的半球效应。在患者中,erp显示的语言优势并不总是与WADA测试的数据一致。在一名患有左MTL癫痫发作的患者中,尽管WADA测试认为该患者的左半球语言占优势,但发现具有言语材料和图形的erp明显偏侧于右半球。
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Language-related hemispheric asymmetry in healthy subjects and patients with temporal lobe epilepsy as studied by event-related brain potentials and intracarotid amobarbital test

There are current attempts to replace the WADA test for pre-surgical evaluation of hemispheric language capabilities by one of the methods of functional brain imaging. Recent PET and fMRI studies using verbal cognitive tasks like verb generation, semantic monitoring or semantic (`deep') encoding of words showed asymmetries of activation in the fronto-lateral cortex. In a previous ERP study subjects were required to indicate whether pronounceable non-words and abstract geometric figures were presented for the first time (`new item') or whether they had been shown before (`old item'). Group analyses of this study showed significant material-specific hemispheric asymmetries with ERPs being more negative-going in recordings of the posterior part of the left hemisphere with verbal material (CP5/6) but more negative-going in recordings of the right hemisphere with the spatial material (P7/8). The aim of the present study was to test statistically ERP lateralization effects in individual healthy subjects as well as WADA-tested patients suffering from seizures of the mesio-temporal lobe (MTL). In all subjects ERP lateralization with verbal material was tested in the electrode pair CP5/6, and ERP lateralization with figures in the electrode pair P7/8. Statistical analyses of single trials showed that in 20 out of 24 subjects ERPs with verbal material started to be more negative-going in CP5 as compared to CP6 in the period between 100 and 200 ms after stimulus onset or the subsequent time epoch (200–300 ms). In one subject not CP5/6 but the closely adjacent electrode pair P7/P8 showed this verbal material-related hemispheric effect. In patients language dominance as indicated by ERPs was not always consistent with the data of the WADA test. In one patient with left MTL seizures ERPs with verbal material and figures were found to be significantly lateralized to the right hemisphere although the WADA test assigned this patient to have a language-dominant left hemisphere.

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