[猪实验性肝+小肠移植对热缺血耐受能力低于小肠的肝移植物的保护技术]。

J P Richer, J P Faure, T Dugue, F Journe, D Bon, N Maillot, D Mothes, J Barbier, M Carretier
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引用次数: 0

摘要

多脏器和原位肝/小肠移植已被用于治疗肠外营养引起的肝功能衰竭相关的肠衰竭患者。本实验研究的目的是确定在猪肝和肠缺血时间之间达到最佳折衷的实验性肝-小肠收获和移植技术。肝的初始门脉血运重建缩短了肝冷缺血后的热缺血时间,将移植物浸泡在4℃的乳酸林格氏液中制备,降低了移植物原发性无功能的风险。
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[Technique for protecting the liver graft less tolerant than the small bowel to heat-induced ischemia in experimental liver + small bowel transplantation in swine].

Multivisceral and orthotopic liver/small bowel transplantations have been performed to treat patients with intestinal failure associated with liver failure induced by parenteral nutrition. The aim of this experimental study was to determine the experimental liver-small bowel harvesting and transplantation technique that achieves the best compromise between liver and intestine ischemia times in pigs. Initial portal revascularization of the liver which reduces the hepatic warm ischemia time after cold ischemia preparation of the graft immersed in lactated ringer's solution at 4 degrees C, reduce the risk of primary non function of the graft.

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