一些n -磺化-2-取代苯并咪唑和咪唑[4,5-b]吡啶的合成及抗增殖活性。

Anti-cancer drug design Pub Date : 1998-12-01

L Garuti, L Varoli, C Cermelli, G Baggio, L Lupo, M Malagoli, M Castelli

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引用次数: 0

摘要

合成了一些n -磺化-2-取代苯并咪唑和咪唑[4,5-b]-吡啶，并在体外测试了它们的抗病毒和抗增殖活性。没有一种化合物具有抗病毒特性。然而，其中三种在微摩尔浓度下抑制白血病和淋巴瘤细胞系的增殖。抗增殖活性的最大效力与两个杂环之间存在乙烯间隔剂有关。

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Synthesis and antiproliferative activity of some N-sulphonated-2-substituted benzimidazoles and imidazo[4,5-b]pyridines.

Some N-sulphonated-2-substituted benzimidazoles and imidazo[4,5-b]-pyridines were synthesized and tested in vitro for antiviral and antiproliferative activity. None of the compounds had antiviral properties. However, three of them inhibited the proliferation of leukaemia and lymphoma cell lines at micromolar concentrations. The maximum potency of antiproliferative activity is correlated with the presence of an ethylenic spacer between the two heterocycles.

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Anti-cancer drug design

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