儿童脑膜瘤。

Di Rocco C, Di Rienzo A
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引用次数: 18

摘要

脑膜瘤是儿科人群中罕见的颅内肿瘤。大多数关于这些肿瘤的报道都强调了一些与成人肿瘤相比较的显著特征。除了发病率较低外,还强调了几乎相等的性别分布,相对常见的幕下位置和在心室系统内的频繁发展。儿童脑膜瘤的预后不良也有作者声称,这可能是由于可能更具侵略性的行为,考虑到这些肿瘤通常在诊断时达到巨大的体积,手术切除困难,复发率高。最近一系列的分析挑战了儿童脑膜瘤实际上比发生在老年患者的类似肿瘤预后更差的概念。事实上,手术技术的改进提高了肿瘤完全切除的百分比。更好的组织学描述使高度侵袭性脑膜肿瘤得以识别,而在过去,这种肿瘤没有得到适当的区分,因此在儿科人群中,肿瘤复发的发生率明显更高。当研究局限于脑膜瘤的“经典”形式时,很明显,儿童脑膜瘤的表现并不比成人脑膜瘤更具侵略性。
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Meningiomas in childhood.

Meningiomas are rare intracranial neoplasms in the pediatric population. Most of the reports concerning these tumors have stressed some distinguishing features comparable with the adult counterpart. Besides the lower incidence, the nearly equal sex distribution, the relatively common infratentorial location and the frequent development within the ventricular system have been emphasized. A poor prognosis of pediatric meningiomas has also been claimed by authors who have suggested that this could be owing to a possibly more aggressive behavior, accounting for the huge size that these tumors have usually reached at diagnosis, the difficult surgical excision, and the higher recurrence rate. The analysis of recent series challenges the concept that pediatric meningiomas do actually bear a worse prognosis than similar tumors occurring in older patients. Improved surgical techniques have in fact resulted in higher percentages of complete tumor removal. Better histological delineation has allowed the identification of highly aggressive meningeal neoplasms, which in the past were not differentiated properly, thus contributing to the apparent higher incidence of recurrent tumors in the pediatric population. When the studies are limited to the "classical" form of meningioma, it becomes apparent that pediatric meningiomas do not behave more aggressively than meningiomas in adult patients.

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