从绿壳贻贝(Perna canaliculus)中分离的Brevetoxin B4,是纽西兰造成贝类神经毒性中毒的主要毒素。

A Morohashi, M Satake, H Naoki, H F Kaspar, Y Oshima, T Yasumoto
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引用次数: 73

摘要

从新西兰小管贝(Perna canaliculus)神经毒性贝类中毒事件发生时采集的绿壳贻贝中分离出一种新的短壳毒素B类似物B4 (BTXB4)作为主要毒素。新的类似物占贝类小鼠致死率的近三分之二,并被确定为n -肉豆肉酰- btxb2和n -棕榈酰- btxb2的混合物。
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Brevetoxin B4 isolated from greenshell mussels Perna canaliculus, the major toxin involved in neurotoxic shellfish poisoning in New Zealand.

A new brevetoxin B analog, brevetoxin B4 (BTXB4), was isolated as the major toxin in greenshell mussels, Perna canaliculus, collected in New Zealand at the time of the neurotoxic shellfish poisoning incident. The new analog accounted for nearly two-thirds of the mouse lethality of the shellfish and was determined to be a mixture of N-myristoyl-BTXB2 and N-palmitoyl-BTXB2.

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Erratum: Alfonso D, Johnson HA, Colman-Saizarbitoria T, Presley CP, McCabe GP, McLaughlin JL (1996): SARs of annonaceous acetogenins in rat liver mitochondria. Nat Toxins 4:181-188. Advances in detection methods for fungal and algal toxins. HPLC/MS analysis of fusarium mycotoxins, fumonisins and deoxynivalenol. Neuronal binding of tetanus toxin compared to its ganglioside binding fragment (H(c)). A new type sandwich immunoassay for microcystin: production of monoclonal antibodies specific to the immune complex formed by microcystin and an anti-microcystin monoclonal antibody.
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