Z Dibbs, K Kurrelmeyer, D Kalra, Y Seta, F Wang, B Bozkurt, G Baumgarten, N Sivasubramanian, D L Mann
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Cytokines in heart failure: pathogenetic mechanisms and potential treatment.
Recent studies have shown that patients with heart failure overexpress a class of biologically active molecules, generically referred to as pro-inflammatory cytokines. This article will review recent clinical and experimental material that suggests that pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha), interleukin-1 (IL-1), and interleukin-6 (IL-6) may play a role in the pathogenesis of congestive heart failure. In addition, we will review recent studies that suggest that antagonizing cytokines may represent a novel target for heart failure therapy.
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