{"title":"5-HT1P受体介导的豚鼠肠系膜下神经节神经元缓慢去极化。","authors":"L C Wang, S R Cai, Z X Huang, Q L Shao, R C Ma","doi":"","DOIUrl":null,"url":null,"abstract":"<p><strong>Aim: </strong>To study the effects of several 5-hydroxytryptamine (5-HT) receptor subtype antagonists on 5-HT-induced depolarization and the effects of 5-HT1P receptor agonist on the membrane potential in the neurons of guinea pig inferior mesenteric ganglion (IMG).</p><p><strong>Methods: </strong>Intracellular recordings were made from neurons of the isolated guinea pig IMG.</p><p><strong>Results: </strong>Cyproheptadine (5-HT1/2 antagonist 10 mumol.L-1, n = 7) and BRL 24924 (5-HT1P antagonist 10 mumol.L-1, n = 19) reversibly suppressed 5-HT slow response; pressure ejection of MCPP (5-HT1P agonist 10 mmol.L-1) induced a slow depolarization in most of 5-HT sensitive neurons (10/14).</p><p><strong>Conclusion: </strong>5-HT-induced slow depolarization is mediated by 5-HT1P receptor.</p>","PeriodicalId":24002,"journal":{"name":"Zhongguo yao li xue bao = Acta pharmacologica Sinica","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1999-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"5-HT1P receptor-mediated slow depolarization in neurons of guinea pig inferior mesenteric ganglion.\",\"authors\":\"L C Wang, S R Cai, Z X Huang, Q L Shao, R C Ma\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Aim: </strong>To study the effects of several 5-hydroxytryptamine (5-HT) receptor subtype antagonists on 5-HT-induced depolarization and the effects of 5-HT1P receptor agonist on the membrane potential in the neurons of guinea pig inferior mesenteric ganglion (IMG).</p><p><strong>Methods: </strong>Intracellular recordings were made from neurons of the isolated guinea pig IMG.</p><p><strong>Results: </strong>Cyproheptadine (5-HT1/2 antagonist 10 mumol.L-1, n = 7) and BRL 24924 (5-HT1P antagonist 10 mumol.L-1, n = 19) reversibly suppressed 5-HT slow response; pressure ejection of MCPP (5-HT1P agonist 10 mmol.L-1) induced a slow depolarization in most of 5-HT sensitive neurons (10/14).</p><p><strong>Conclusion: </strong>5-HT-induced slow depolarization is mediated by 5-HT1P receptor.</p>\",\"PeriodicalId\":24002,\"journal\":{\"name\":\"Zhongguo yao li xue bao = Acta pharmacologica Sinica\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1999-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Zhongguo yao li xue bao = Acta pharmacologica Sinica\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Zhongguo yao li xue bao = Acta pharmacologica Sinica","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
目的:研究几种5-羟色胺(5-HT)受体亚型拮抗剂对豚鼠肠系膜下神经节(IMG)神经元去极化的影响及5-羟色胺受体激动剂对神经元膜电位的影响。方法:对离体豚鼠IMG神经元进行细胞内记录。结果:赛庚啶(5-HT1/2拮抗剂)10mumol;L-1, n = 7)和BRL 24924 (5-HT1P拮抗剂10 μ mol)。L-1, n = 19)可逆抑制5-HT慢反应;MCPP (5-HT1P激动剂10 mmol.L-1)的压力射血诱导大多数5-HT敏感神经元缓慢去极化(10/14)。结论:5-HT1P受体介导5-HT1P诱导的慢去极化。
5-HT1P receptor-mediated slow depolarization in neurons of guinea pig inferior mesenteric ganglion.
Aim: To study the effects of several 5-hydroxytryptamine (5-HT) receptor subtype antagonists on 5-HT-induced depolarization and the effects of 5-HT1P receptor agonist on the membrane potential in the neurons of guinea pig inferior mesenteric ganglion (IMG).
Methods: Intracellular recordings were made from neurons of the isolated guinea pig IMG.
Results: Cyproheptadine (5-HT1/2 antagonist 10 mumol.L-1, n = 7) and BRL 24924 (5-HT1P antagonist 10 mumol.L-1, n = 19) reversibly suppressed 5-HT slow response; pressure ejection of MCPP (5-HT1P agonist 10 mmol.L-1) induced a slow depolarization in most of 5-HT sensitive neurons (10/14).
Conclusion: 5-HT-induced slow depolarization is mediated by 5-HT1P receptor.
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