哺乳动物肾脏中肾单位的数量:环境影响起决定性作用。

M Lelièvre-Pégorier, C Merlet-Bénichou
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引用次数: 41

摘要

一些主要来自动物研究的证据表明,胎儿环境的变化可能会影响肾脏的发育。在人类和动物中,胎儿生长迟缓都与肾元缺陷有关。胎儿维生素A供给的变化可能是人体肾脏中肾单位数量变化的原因。在子宫内暴露于高血糖或药物也可引起肾元缺陷。
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The number of nephrons in the mammalian kidney: environmental influences play a determining role.

Several lines of evidence, mostly derived from animal studies, indicate that changes in the fetal environment may affect the renal development. Fetal growth retardation is associated with a nephron deficit in both humans and animals. Changes in the supply of vitamin A to the fetus may be responsible for the variations in the number of nephrons in the human kidney. In utero exposure to hyperglycemia or drugs may also cause a nephron deficit.

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