[异位心脏移植:贝勒医学院卫理公会医院13年的经验]。

E Herrera Garza, G P Noon, J B Durand, S J Stetson, S Zylicz, L Johnson, R Cano Niño, F Herrera Flores, G Torre-Amione
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引用次数: 0

摘要

未标记:为了评价我们在异位心脏移植方面的经验,我们对接受该手术的患者的临床档案进行了回顾性分析。结果:我院共完成心脏移植手术405例。24例(5.9%)为异位移植物。I组(12例)的适应症为不可逆肺动脉高压,II组(剩余12例)的适应症为边缘移植物或大小不匹配。两组表现出相似的人口统计学特征,I组的生存率稍好一些。I组的9名患者表现出早期肺压降低,并在一年内正常化。结论:异位心脏支持天然心室功能。在9例患者中,异位心脏使先前认为不可逆转的肺动脉高压状态得以逆转。这一发现支持在慢性基础上使用肺血管扩张剂或在移植前使用左心室辅助装置,目的是使肺压力正常化,使患者成为原位心脏移植的候选者,从而避免异位心脏移植的必要性。
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[Heterotopic heart transplantation: 13-year experience at the Methodist Hospital of the Baylor Medical College].

Unlabelled: In order to evaluate our experience in heterotopic cardiac transplantation, we conducted a retrospective analysis of the clinical files of patients who underwent this procedure.

Results: A total of 405 heart transplants were performed in our institution. In 24 (5.9%), the grafts were placed heterotopically. In group I (12 patients), the indication was irreversible pulmonary hypertension and in group II (remaining 12 patients), it was marginal grafts or size mismatch. Both groups demonstrated similar demographics and the survival rate was slightly better in group I. Nine patients from group I demonstrated an early reduction in pulmonary pressures which normalized in one year.

Conclusions: The heterotopic heart supports the function of the native ventricles. In 9 patients, the heterotopic heart enables the reversal of a state of pulmonary hypertension previously thought to be irreversible. This finding supports the use of pulmonary vaso-dilators on a chronic basis or the use of a left ventricular assist device pre-transplant with the intention of normalizing pulmonary pressures and allowing the patients to become candidates for orthotopic cardiac transplantation and thereby avoiding the necessity of heterotopic cardiac transplantation.

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