E M Krupitskiĭ, G F Karandashova, V V Vostrikov, N M Lavrova, N I Grinenko, T Iu Slavina, A Ia Grinenko
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[Ethanol inhibits platelet monoamine oxidase type B activity in patients with alcoholism].
The influence of 400 mM ethanol on the activity of monoamine oxidase type B (MAO-B) of blood platelets has been studied in vitro in 30 alcoholic patients and 30 healthy volunteers. Benzylamine was used as a substrate for MAO-B. MAO-B inhibition by ethanol was higher in alcoholics compared to healthy volunteers. The higher vulnerability of MAO-B of alcoholics inhibiting action to of ethanol may be one of the mechanisms underlying some symptoms of alcoholism.
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