精氨酸酶在肾小球肾炎中的作用。

S N Waddington, V Cattell
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引用次数: 21

摘要

精氨酸酶将l -精氨酸代谢为l -鸟氨酸和尿素。已经确定了两种精氨酸酶亚型,AI(肝精氨酸酶)和AII(普遍表达,功能未知)。很明显,精氨酸酶除了在炎症部位产生高浓度尿素外,还可能发挥重要作用。调节通过细胞因子、底物竞争和一氧化氮(NO)代谢产物发生。精氨酸酶在炎症部位的功能尚不清楚,但可能包括调节细胞凋亡和NO的产生以及结构和细胞蛋白前体的生成。在肾小球肾炎中,肾小球精氨酸酶活性增加,其模式与伤口愈合相似。NO抑制可进一步提高该水平,提示底物竞争。炎症肾小球的潜在来源包括浸润的白细胞和系膜细胞,主要表达的亚型是AI (AII在生理条件下占优势)。最近对精氨酸酶不同亚型的鉴定是了解精氨酸酶活性在肾小球肾炎中的意义的重要一步。
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Arginase in glomerulonephritis.

Arginase metabolizes L-arginine to L-ornithine and urea. Two arginase isoforms, AI (liver arginase) and AII (ubiquitously expressed, functions unknown), have been identified. It is clear that arginases potentially have important roles in addition to urea generation for high concentrations are present at inflammatory sites. Regulation occurs through cytokines, substrate competition and products of nitric oxide (NO) metabolism. The functions of arginases at inflammatory sites are unknown, but may include regulation of apoptosis and NO production and generation of structural and cellular protein precursors. In glomerulonephritis there is increased arginase activity in nephritic glomeruli following a pattern similar to that in wound healing. The level can be further increased by NO inhibition suggesting substrate competition. The potential sources in the inflamed glomerulus include infiltrating leucocytes and mesangial cells, and the predominant isoform expressed is AI (AII predominates under physiological conditions). The recent identification of different isoforms of arginase has been an important step towards understanding the significance of arginase activity in glomerulonephritis.

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