{"title":"IFN-α和IFN-β:免疫记忆和慢性炎症之间的联系","authors":"Arne N Akbar , Janet M Lord , Mike Salmon","doi":"10.1016/S0167-5699(00)01652-2","DOIUrl":null,"url":null,"abstract":"<div><p>The majority of expanded T cells generated during an immune response are cleared by apoptosis. Prevention of death in some activated T cells enables the persistence of a memory T-cell pool. Here, observations that IFN-α and IFN-β inhibit activated T-cell apoptosis are described. Although this enables memory T cells to persist without antigen, excessive IFN-α or IFN-γ secretion might lead to chronic inflammation.</p></div>","PeriodicalId":73346,"journal":{"name":"Immunology today","volume":"21 7","pages":"Pages 337-342"},"PeriodicalIF":0.0000,"publicationDate":"2000-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0167-5699(00)01652-2","citationCount":"147","resultStr":"{\"title\":\"IFN-α and IFN-β: a link between immune memory and chronic inflammation\",\"authors\":\"Arne N Akbar , Janet M Lord , Mike Salmon\",\"doi\":\"10.1016/S0167-5699(00)01652-2\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The majority of expanded T cells generated during an immune response are cleared by apoptosis. Prevention of death in some activated T cells enables the persistence of a memory T-cell pool. Here, observations that IFN-α and IFN-β inhibit activated T-cell apoptosis are described. Although this enables memory T cells to persist without antigen, excessive IFN-α or IFN-γ secretion might lead to chronic inflammation.</p></div>\",\"PeriodicalId\":73346,\"journal\":{\"name\":\"Immunology today\",\"volume\":\"21 7\",\"pages\":\"Pages 337-342\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2000-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/S0167-5699(00)01652-2\",\"citationCount\":\"147\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Immunology today\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0167569900016522\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Immunology today","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0167569900016522","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
IFN-α and IFN-β: a link between immune memory and chronic inflammation
The majority of expanded T cells generated during an immune response are cleared by apoptosis. Prevention of death in some activated T cells enables the persistence of a memory T-cell pool. Here, observations that IFN-α and IFN-β inhibit activated T-cell apoptosis are described. Although this enables memory T cells to persist without antigen, excessive IFN-α or IFN-γ secretion might lead to chronic inflammation.
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