Assignment of the human RhoHP1 gene (ARHD) to chromosome 11q14.3 by radiation hybrid mapping.

The Rho (represents Ras homologous) related protein HP1 (RhoHP1) was isolated from a human placenta cDNA library. RhoHP1 showed 50–54% sequence homology to members of the Rho family (Shimizu et al.,1997). The Rho proteins directly interact with protein kinases, which may serve as downstream effector targets of the activated GTPase (Vincent et al., 1997). The Rho family proteins play a critical role in muscle differentiation by regulating the expression of the myogenin and MEF2 genes (Takano et al., 1998). In this report, a radiation hybrid mapping panel was used to assign the RhoHP1 gene ARHD (ras homolog gene family, member D) to chromosome 11q14.3.