M Little , S.M Kipriyanov , F Le Gall , G Moldenhauer
{"title":"小鼠和人:杂交瘤和重组抗体","authors":"M Little , S.M Kipriyanov , F Le Gall , G Moldenhauer","doi":"10.1016/S0167-5699(00)01668-6","DOIUrl":null,"url":null,"abstract":"<div><p>Thousands of mouse monoclonal antibodies have been produced from hybridomas over the past 25 years. The same technique can now be used to clone human antibodies from transgenic mice. Full-length antibodies and recombinant fragments engineered for various diagnostic and therapeutic applications can be obtained in reasonably large amounts after expression in mammalian cells, milk and plants.</p></div>","PeriodicalId":73346,"journal":{"name":"Immunology today","volume":"21 8","pages":"Pages 364-370"},"PeriodicalIF":0.0000,"publicationDate":"2000-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0167-5699(00)01668-6","citationCount":"176","resultStr":"{\"title\":\"Of mice and men: hybridoma and recombinant antibodies\",\"authors\":\"M Little , S.M Kipriyanov , F Le Gall , G Moldenhauer\",\"doi\":\"10.1016/S0167-5699(00)01668-6\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Thousands of mouse monoclonal antibodies have been produced from hybridomas over the past 25 years. The same technique can now be used to clone human antibodies from transgenic mice. Full-length antibodies and recombinant fragments engineered for various diagnostic and therapeutic applications can be obtained in reasonably large amounts after expression in mammalian cells, milk and plants.</p></div>\",\"PeriodicalId\":73346,\"journal\":{\"name\":\"Immunology today\",\"volume\":\"21 8\",\"pages\":\"Pages 364-370\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2000-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/S0167-5699(00)01668-6\",\"citationCount\":\"176\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Immunology today\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0167569900016686\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Immunology today","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0167569900016686","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Of mice and men: hybridoma and recombinant antibodies
Thousands of mouse monoclonal antibodies have been produced from hybridomas over the past 25 years. The same technique can now be used to clone human antibodies from transgenic mice. Full-length antibodies and recombinant fragments engineered for various diagnostic and therapeutic applications can be obtained in reasonably large amounts after expression in mammalian cells, milk and plants.
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