Stephen M Rich , Marcelo Urbano Ferreira , Francisco J Ayala
{"title":"恶性疟原虫抗原多样性的起源","authors":"Stephen M Rich , Marcelo Urbano Ferreira , Francisco J Ayala","doi":"10.1016/S0169-4758(00)01741-5","DOIUrl":null,"url":null,"abstract":"<div><p>Most studies of genetic variability of <em>Plasmodium falciparum</em> have focused on protein antigens and the genes that encode them. The consensus is that populations exhibit high levels of genetic polymorphism, most notably the genes encoding surface proteins of the merozoite (<em>Msp1</em>, <em>Msp2</em>) and the sporozoite (<em>Csp</em>). The age and derivation of this variation is a subject that warrants further careful consideration, as discussed here by Stephen Rich, Marcelo Ferreira and Francisco Ayala.</p></div>","PeriodicalId":80110,"journal":{"name":"Parasitology today (Personal ed.)","volume":"16 9","pages":"Pages 390-396"},"PeriodicalIF":0.0000,"publicationDate":"2000-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0169-4758(00)01741-5","citationCount":"60","resultStr":"{\"title\":\"The Origin of Antigenic Diversity in Plasmodium falciparum\",\"authors\":\"Stephen M Rich , Marcelo Urbano Ferreira , Francisco J Ayala\",\"doi\":\"10.1016/S0169-4758(00)01741-5\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Most studies of genetic variability of <em>Plasmodium falciparum</em> have focused on protein antigens and the genes that encode them. The consensus is that populations exhibit high levels of genetic polymorphism, most notably the genes encoding surface proteins of the merozoite (<em>Msp1</em>, <em>Msp2</em>) and the sporozoite (<em>Csp</em>). The age and derivation of this variation is a subject that warrants further careful consideration, as discussed here by Stephen Rich, Marcelo Ferreira and Francisco Ayala.</p></div>\",\"PeriodicalId\":80110,\"journal\":{\"name\":\"Parasitology today (Personal ed.)\",\"volume\":\"16 9\",\"pages\":\"Pages 390-396\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2000-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/S0169-4758(00)01741-5\",\"citationCount\":\"60\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Parasitology today (Personal ed.)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0169475800017415\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Parasitology today (Personal ed.)","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0169475800017415","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The Origin of Antigenic Diversity in Plasmodium falciparum
Most studies of genetic variability of Plasmodium falciparum have focused on protein antigens and the genes that encode them. The consensus is that populations exhibit high levels of genetic polymorphism, most notably the genes encoding surface proteins of the merozoite (Msp1, Msp2) and the sporozoite (Csp). The age and derivation of this variation is a subject that warrants further careful consideration, as discussed here by Stephen Rich, Marcelo Ferreira and Francisco Ayala.
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