{"title":"寄生虫蛋白质组学","authors":"John Barrett, Jim Jefferies, Peter Brophy","doi":"10.1016/S0169-4758(00)01739-7","DOIUrl":null,"url":null,"abstract":"<div><p>Proteomics<span> offers a new set of tools for investigating parasites and parasite-associated disease. In this article, John Barrett, Jim Jefferies and Peter Brophy describe the key technologies involved, including two-dimensional gel electrophoresis, image analysis, biological mass spectroscopy and database searching. The potential applications of proteomics in drug and vaccine discovery are reviewed, as are possible future developments.</span></p></div>","PeriodicalId":80110,"journal":{"name":"Parasitology today (Personal ed.)","volume":"16 9","pages":"Pages 400-403"},"PeriodicalIF":0.0000,"publicationDate":"2000-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0169-4758(00)01739-7","citationCount":"26","resultStr":"{\"title\":\"Parasite Proteomics\",\"authors\":\"John Barrett, Jim Jefferies, Peter Brophy\",\"doi\":\"10.1016/S0169-4758(00)01739-7\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Proteomics<span> offers a new set of tools for investigating parasites and parasite-associated disease. In this article, John Barrett, Jim Jefferies and Peter Brophy describe the key technologies involved, including two-dimensional gel electrophoresis, image analysis, biological mass spectroscopy and database searching. The potential applications of proteomics in drug and vaccine discovery are reviewed, as are possible future developments.</span></p></div>\",\"PeriodicalId\":80110,\"journal\":{\"name\":\"Parasitology today (Personal ed.)\",\"volume\":\"16 9\",\"pages\":\"Pages 400-403\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2000-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/S0169-4758(00)01739-7\",\"citationCount\":\"26\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Parasitology today (Personal ed.)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0169475800017397\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Parasitology today (Personal ed.)","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0169475800017397","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 26
摘要
蛋白质组学为研究寄生虫和寄生虫相关疾病提供了一套新的工具。在本文中，John Barrett, Jim Jefferies和Peter Brophy描述了所涉及的关键技术，包括二维凝胶电泳，图像分析，生物质谱和数据库检索。回顾了蛋白质组学在药物和疫苗发现中的潜在应用，以及可能的未来发展。
Proteomics offers a new set of tools for investigating parasites and parasite-associated disease. In this article, John Barrett, Jim Jefferies and Peter Brophy describe the key technologies involved, including two-dimensional gel electrophoresis, image analysis, biological mass spectroscopy and database searching. The potential applications of proteomics in drug and vaccine discovery are reviewed, as are possible future developments.
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