Moira E Bruce , Karen L Brown , Neil A Mabbott , Christine F Farquhar , Martin Jeffrey
{"title":"卵泡树突状细胞在TSE发病机制中的作用","authors":"Moira E Bruce , Karen L Brown , Neil A Mabbott , Christine F Farquhar , Martin Jeffrey","doi":"10.1016/S0167-5699(00)01696-0","DOIUrl":null,"url":null,"abstract":"<div><p>The pathogenesis of transmissible spongiform encephalopathies (TSEs) often includes a replication phase in lymphoid tissues before infection spreads to the central nervous system. Recent studies show that the follicular dendritic cells of the germinal centres are critical for this replication. These cells are therefore potential targets for therapy or prophylaxis in natural TSEs, such as variant Creutzfeldt-Jakob disease.</p></div>","PeriodicalId":73346,"journal":{"name":"Immunology today","volume":"21 9","pages":"Pages 442-446"},"PeriodicalIF":0.0000,"publicationDate":"2000-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0167-5699(00)01696-0","citationCount":"75","resultStr":"{\"title\":\"Follicular dendritic cells in TSE pathogenesis\",\"authors\":\"Moira E Bruce , Karen L Brown , Neil A Mabbott , Christine F Farquhar , Martin Jeffrey\",\"doi\":\"10.1016/S0167-5699(00)01696-0\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The pathogenesis of transmissible spongiform encephalopathies (TSEs) often includes a replication phase in lymphoid tissues before infection spreads to the central nervous system. Recent studies show that the follicular dendritic cells of the germinal centres are critical for this replication. These cells are therefore potential targets for therapy or prophylaxis in natural TSEs, such as variant Creutzfeldt-Jakob disease.</p></div>\",\"PeriodicalId\":73346,\"journal\":{\"name\":\"Immunology today\",\"volume\":\"21 9\",\"pages\":\"Pages 442-446\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2000-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/S0167-5699(00)01696-0\",\"citationCount\":\"75\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Immunology today\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0167569900016960\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Immunology today","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0167569900016960","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The pathogenesis of transmissible spongiform encephalopathies (TSEs) often includes a replication phase in lymphoid tissues before infection spreads to the central nervous system. Recent studies show that the follicular dendritic cells of the germinal centres are critical for this replication. These cells are therefore potential targets for therapy or prophylaxis in natural TSEs, such as variant Creutzfeldt-Jakob disease.
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