简要回顾:人类间期染色体的形态和功能。

E Chevret, E V Volpi, D Sheer
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引用次数: 44

摘要

间期染色体的一个关键特征是它们在细胞核中被压缩成离散的“区域”。在这篇综述中,我们将重点关注这种组织赋予基因组的区隔化,并评估我们目前对大规模染色质折叠在基因表达调控中的作用的理解。我们研究了转录发生在染色体外表面的假设的证据,并遵循其进化,包括染色体内富含染色质结构域表面的转录。我们还提出了关于大规模染色质折叠的细节和染色质与神秘核基质之间的功能关系的流行观点。
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Mini review: form and function in the human interphase chromosome.

A key feature of interphase chromosomes is their compaction into discrete "territories" in the nucleus. In this review, we focus on the compartmentalization of the genome conferred by this organization and evaluate our current understanding of the role of large-scale chromatin folding in the regulation of gene expression. We examine evidence for the hypothesis that transcription occurs at the external surfaces of chromosomes and follow its evolution to include transcription at the surfaces of chromatin-rich domains within chromosomes. We also present prevailing views regarding the details of large-scale chromatin folding and the functional relationship between chromatin and the enigmatic nuclear matrix.

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