人分泌素(SCT):基因结构、染色体位置和mRNA的分布。

T E Whitmore, J L Holloway, C E Lofton-Day, M F Maurer, L Chen, T J Quinton, J B Vincent, S W Scherer, S Lok
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引用次数: 38

摘要

分泌素是一种内分泌激素,能刺激富含碳酸氢盐的胰液分泌。最近,有人讨论分泌素缺乏可能与自闭症综合症有关,这表明这种激素除了在消化中起作用外,还可能具有神经内分泌功能。本研究从细菌人工染色体基因组文库中分离出人分泌素基因(SCT)。SCT包含4个外显子,蛋白质编码区跨越基因组DNA的713 bp。人类SCT在结构上与其他物种的分泌素基因相似。然而,氨基酸保护在编码具有生物活性的成熟肽的外显子中最为明显。Northern blot分析显示,人类SCT转录本位于脾脏、肠道和大脑。辐射杂交定位将SCT位点定位在11p15.5染色体上。
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Human secretin (SCT): gene structure, chromosome location, and distribution of mRNA.

Secretin is an endocrine hormone that stimulates the secretion of bicarbonate-rich pancreatic fluids. Recently, it has been discussed that secretin deficiency may be implicated in autistic syndrome, suggesting that the hormone could have a neuroendocrine function in addition to its role in digestion. In the present study, the human secretin gene (SCT) was isolated from a bacterial artificial chromosome genomic library. SCT contains four exons, with the protein coding regions spanning 713 bp of genomic DNA. Human SCT is similar structurally to the secretin genes of other species. Amino acid conservation, however, is most pronounced within the exon encoding the biologically active mature peptide. Northern blot analysis shows that human SCT transcripts are located in the spleen, intestinal tract, and brain. Radiation hybrid mapping places the SCT locus on chromosome 11p15.5.

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