[胰岛素合成片段包被脂质体与pc12细胞的特异性相互作用]。

Voprosy meditsinskoi khimii Pub Date : 2000-07-01

D L Maslov, V N Prozorovskiĭ

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引用次数: 0

摘要

合成的肽代表了与胰岛素受体结合的重要功能位点。肽I的氨基酸与胰岛素的b链B19-B26和a链A20-A21位置相关。肽II的氨基酸与胰岛素B23-B26的b链和A20-A21的a链相关。结果表明，这些肽增加了脂质体结合，随后是受体介导的细胞PC12内吞作用。

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[Specific interaction of liposomes coated by insulin synthetic fragments with PC 12 cells].

The synthesized peptides represent the functionally important site for binding to insulin receptor. Amino acids of peptide I correlate with B-chain of insulin at the position B19-B26 and A-chain at the position A20-A21. Amino acids of peptide II correlate with B-chain of insulin at position B23-B26 and A-chain at the position A20-A21. It was shown, that the these peptides increased liposomal binding followed by receptor-mediated endocytosis by cells PC12.

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Voprosy meditsinskoi khimii

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