Ada M Kruisbeek , Mariëlle C Haks , Michael Carleton , David L Wiest , Alison M Michie , Juan Carlos Zúñiga-Pflücker
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Branching out to gain control: how the pre-TCR is linked to multiple functions
How is signaling specificity achieved by the pre-TCR during selection of T-cell fate? Like the TCR, this receptor controls many functions, and recent studies define which pathways couple the pre-TCR to the molecular events controlling survival, proliferation, allelic exclusion at the TCRβ locus, and further differentiation.
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