用区域特异性颜料绘制水貂染色体5q的Zoo-FISH:人类、猪和狐狸染色体间和染色体内重排的描绘。

N B Rubtsov, T V Karamisheva, N M Astakhova, T Liehr, U Claussen, N S Zhdanova
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引用次数: 38

摘要

用显微解剖绘画探针对与人类17号染色体同源的进化保守哺乳动物染色体进行比较,发现水貂和猪的这些染色体内重排,而狐狸的这一保守区域被破坏。对伊比利亚鼩染色体同源区域的检测表明,微解剖绘画探针在描绘属于至少1亿年前分化的物种的同源染色体区域方面是有效的。
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Zoo-FISH with region-specific paints for mink chromosome 5q: delineation of inter- and intrachromosomal rearrangements in human, pig, and fox.

Comparison of evolutionarily conserved mammalian chromosomes homologous to human chromosome 17, performed with microdissected painting probes, revealed rearrangements inside these chromosomes in mink and pig and a disruption of this conserved region in the fox. Detection of a homologous region on an Iberian shrew chromosome showed the efficiency of microdissected painting probes for delineation of homologous chromosome regions in species belonging to orders that diverged at least 100 million years ago.

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