{"title":"经颅磁刺激对人体运动生理学的研究。","authors":"R Chen","doi":"10.1002/1097-4598(2000)999:9<::aid-mus6>3.0.co;2-i","DOIUrl":null,"url":null,"abstract":"<p><p>Transcranial magnetic stimulation (TMS) is a safe, noninvasive, and painless way to stimulate the human motor cortex in behaving human subjects. When it is applied as a single-pulse, measurements such as central conduction time, motor threshold, silent-period duration, recruitment curve, and mapping of muscle representation can be determined. Paired-pulse TMS is a useful way to examine cortical excitability. Single and paired-pulse TMS have been applied to study plasticity following amputation and cortical excitability in patients with dystonia. Another form of TMS is repetitive TMS (rTMS), with stimuli delivered repeatedly to a single scalp site. High-frequency rTMS can be used to transiently inactivate different cortical areas to study their functions. rTMS can also modulate cortical excitability. At stimulus frequencies higher than 5 Hz, rTMS increases cortical excitability, and stimulation around 1 Hz reduces cortical excitability. Modulation of cortical excitability by rTMS has therapeutic potential in psychiatric and neurological disorders.</p>","PeriodicalId":79355,"journal":{"name":"Muscle & nerve. Supplement","volume":"9 ","pages":"S26-32"},"PeriodicalIF":0.0000,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/1097-4598(2000)999:9<::aid-mus6>3.0.co;2-i","citationCount":"258","resultStr":"{\"title\":\"Studies of human motor physiology with transcranial magnetic stimulation.\",\"authors\":\"R Chen\",\"doi\":\"10.1002/1097-4598(2000)999:9<::aid-mus6>3.0.co;2-i\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Transcranial magnetic stimulation (TMS) is a safe, noninvasive, and painless way to stimulate the human motor cortex in behaving human subjects. When it is applied as a single-pulse, measurements such as central conduction time, motor threshold, silent-period duration, recruitment curve, and mapping of muscle representation can be determined. Paired-pulse TMS is a useful way to examine cortical excitability. Single and paired-pulse TMS have been applied to study plasticity following amputation and cortical excitability in patients with dystonia. Another form of TMS is repetitive TMS (rTMS), with stimuli delivered repeatedly to a single scalp site. High-frequency rTMS can be used to transiently inactivate different cortical areas to study their functions. rTMS can also modulate cortical excitability. At stimulus frequencies higher than 5 Hz, rTMS increases cortical excitability, and stimulation around 1 Hz reduces cortical excitability. Modulation of cortical excitability by rTMS has therapeutic potential in psychiatric and neurological disorders.</p>\",\"PeriodicalId\":79355,\"journal\":{\"name\":\"Muscle & nerve. Supplement\",\"volume\":\"9 \",\"pages\":\"S26-32\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2000-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1002/1097-4598(2000)999:9<::aid-mus6>3.0.co;2-i\",\"citationCount\":\"258\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Muscle & nerve. Supplement\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1002/1097-4598(2000)999:9<::aid-mus6>3.0.co;2-i\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Muscle & nerve. Supplement","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1002/1097-4598(2000)999:9<::aid-mus6>3.0.co;2-i","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Studies of human motor physiology with transcranial magnetic stimulation.
Transcranial magnetic stimulation (TMS) is a safe, noninvasive, and painless way to stimulate the human motor cortex in behaving human subjects. When it is applied as a single-pulse, measurements such as central conduction time, motor threshold, silent-period duration, recruitment curve, and mapping of muscle representation can be determined. Paired-pulse TMS is a useful way to examine cortical excitability. Single and paired-pulse TMS have been applied to study plasticity following amputation and cortical excitability in patients with dystonia. Another form of TMS is repetitive TMS (rTMS), with stimuli delivered repeatedly to a single scalp site. High-frequency rTMS can be used to transiently inactivate different cortical areas to study their functions. rTMS can also modulate cortical excitability. At stimulus frequencies higher than 5 Hz, rTMS increases cortical excitability, and stimulation around 1 Hz reduces cortical excitability. Modulation of cortical excitability by rTMS has therapeutic potential in psychiatric and neurological disorders.
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