Tao Ma, Ye Zhang, Kai Fu, Zhichun Li, Changchun Yuan, Wenbing Ma
{"title":"基于苯并噻唑的过氧化氢荧光探针的设计、合成及性能研究","authors":"Tao Ma, Ye Zhang, Kai Fu, Zhichun Li, Changchun Yuan, Wenbing Ma","doi":"10.1016/j.bioorg.2022.105798","DOIUrl":null,"url":null,"abstract":"<div><p>Abnormal intracellular hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) concentration is related to cancer, cardiovascular, cerebrovascular diseases and other diseases. A novel H<sub>2</sub>O<sub>2</sub> fluorescent probe (<strong>BBS</strong>) was designed and synthesized. The fluorescence intensity shows good linear relationship with the concentration of H<sub>2</sub>O<sub>2</sub> (0–40 μM), and the detection limit is 132 nM. The response mechanism of probe <strong>BBS</strong> was verified and analyzed by UV–Vis spectra, titration spectra and density functional theory (DFT) on Gaussian 09 programme. <strong>BBS</strong> can be used for bioimaging in living cells.</p></div>","PeriodicalId":257,"journal":{"name":"Bioorganic Chemistry","volume":null,"pages":null},"PeriodicalIF":4.5000,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"7","resultStr":"{\"title\":\"Design, synthesis and properties of hydrogen peroxide fluorescent probe based on benzothiazole\",\"authors\":\"Tao Ma, Ye Zhang, Kai Fu, Zhichun Li, Changchun Yuan, Wenbing Ma\",\"doi\":\"10.1016/j.bioorg.2022.105798\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Abnormal intracellular hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) concentration is related to cancer, cardiovascular, cerebrovascular diseases and other diseases. A novel H<sub>2</sub>O<sub>2</sub> fluorescent probe (<strong>BBS</strong>) was designed and synthesized. The fluorescence intensity shows good linear relationship with the concentration of H<sub>2</sub>O<sub>2</sub> (0–40 μM), and the detection limit is 132 nM. The response mechanism of probe <strong>BBS</strong> was verified and analyzed by UV–Vis spectra, titration spectra and density functional theory (DFT) on Gaussian 09 programme. <strong>BBS</strong> can be used for bioimaging in living cells.</p></div>\",\"PeriodicalId\":257,\"journal\":{\"name\":\"Bioorganic Chemistry\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.5000,\"publicationDate\":\"2022-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"7\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Bioorganic Chemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0045206822002036\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bioorganic Chemistry","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0045206822002036","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
Design, synthesis and properties of hydrogen peroxide fluorescent probe based on benzothiazole
Abnormal intracellular hydrogen peroxide (H2O2) concentration is related to cancer, cardiovascular, cerebrovascular diseases and other diseases. A novel H2O2 fluorescent probe (BBS) was designed and synthesized. The fluorescence intensity shows good linear relationship with the concentration of H2O2 (0–40 μM), and the detection limit is 132 nM. The response mechanism of probe BBS was verified and analyzed by UV–Vis spectra, titration spectra and density functional theory (DFT) on Gaussian 09 programme. BBS can be used for bioimaging in living cells.
期刊介绍：
Bioorganic Chemistry publishes research that addresses biological questions at the molecular level, using organic chemistry and principles of physical organic chemistry. The scope of the journal covers a range of topics at the organic chemistry-biology interface, including: enzyme catalysis, biotransformation and enzyme inhibition; nucleic acids chemistry; medicinal chemistry; natural product chemistry, natural product synthesis and natural product biosynthesis; antimicrobial agents; lipid and peptide chemistry; biophysical chemistry; biological probes; bio-orthogonal chemistry and biomimetic chemistry.
For manuscripts dealing with synthetic bioactive compounds, the Journal requires that the molecular target of the compounds described must be known, and must be demonstrated experimentally in the manuscript. For studies involving natural products, if the molecular target is unknown, some data beyond simple cell-based toxicity studies to provide insight into the mechanism of action is required. Studies supported by molecular docking are welcome, but must be supported by experimental data. The Journal does not consider manuscripts that are purely theoretical or computational in nature.
The Journal publishes regular articles, short communications and reviews. Reviews are normally invited by Editors or Editorial Board members. Authors of unsolicited reviews should first contact an Editor or Editorial Board member to determine whether the proposed article is within the scope of the Journal.
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