{"title":"衰老加速小鼠(SAM)颅骨d -天冬氨酸含量的年龄相关变化。","authors":"Susumu Ohtani, Toshiharu Yamamoto, Mieko Sashima, Masanobu Satoh","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>We measured the age-related changes in the D/L-aspartic acid ratio (D/L ratio) of cranial bones in two different sublines of senescence-accelerated mice (SAM/Iw): SAMP2/Iw (SAM, prone 2/Iwate) and SAMR1/Iw (SAM, resistant 1/Iwate). In SAM/Iw under 9 months of age, the D/L ratio in SAMP2/Iw was higher than that in SAMR1/Iw (p<0.001). However, in all 12-month old SAM/Iw, whether SAMP2/Iw or SAMR1/Iw, the D/L ratio was higher in males than in females. There were minor differences in the age-related changes in the D/L ratios between different types of cranial bone. In 1-month old SAM/Iw the rectal temperature was similar in both males and females. However from the age of 2 months, there was a divergence, with the rectal temperature measurement in SAMP2/Iw reaching a peak 2 months of age, whereas SAMR1/Iw had the highest temperature readings at 6 months of age. In both SAMP2/Iw older than 2 months, and SAMR1/Iw older than 6 months, the temperature readings tended to gradually decrease with age in both males and females. These results suggest that the differences in D/L-aspartic acid ratios were dependent on the age, gender, and strain of SAM/Iw, but were not dependant on the type of cranial bone studied. It seems likely that these differences may be related mainly to changes in body temperature.</p>","PeriodicalId":55080,"journal":{"name":"Growth Development and Aging","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Age-related changes in the D-aspartic acid content of the cranial bones in senescence-accelerated mice (SAM).\",\"authors\":\"Susumu Ohtani, Toshiharu Yamamoto, Mieko Sashima, Masanobu Satoh\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>We measured the age-related changes in the D/L-aspartic acid ratio (D/L ratio) of cranial bones in two different sublines of senescence-accelerated mice (SAM/Iw): SAMP2/Iw (SAM, prone 2/Iwate) and SAMR1/Iw (SAM, resistant 1/Iwate). In SAM/Iw under 9 months of age, the D/L ratio in SAMP2/Iw was higher than that in SAMR1/Iw (p<0.001). However, in all 12-month old SAM/Iw, whether SAMP2/Iw or SAMR1/Iw, the D/L ratio was higher in males than in females. There were minor differences in the age-related changes in the D/L ratios between different types of cranial bone. In 1-month old SAM/Iw the rectal temperature was similar in both males and females. However from the age of 2 months, there was a divergence, with the rectal temperature measurement in SAMP2/Iw reaching a peak 2 months of age, whereas SAMR1/Iw had the highest temperature readings at 6 months of age. In both SAMP2/Iw older than 2 months, and SAMR1/Iw older than 6 months, the temperature readings tended to gradually decrease with age in both males and females. These results suggest that the differences in D/L-aspartic acid ratios were dependent on the age, gender, and strain of SAM/Iw, but were not dependant on the type of cranial bone studied. It seems likely that these differences may be related mainly to changes in body temperature.</p>\",\"PeriodicalId\":55080,\"journal\":{\"name\":\"Growth Development and Aging\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2002-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Growth Development and Aging\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Growth Development and Aging","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Age-related changes in the D-aspartic acid content of the cranial bones in senescence-accelerated mice (SAM).
We measured the age-related changes in the D/L-aspartic acid ratio (D/L ratio) of cranial bones in two different sublines of senescence-accelerated mice (SAM/Iw): SAMP2/Iw (SAM, prone 2/Iwate) and SAMR1/Iw (SAM, resistant 1/Iwate). In SAM/Iw under 9 months of age, the D/L ratio in SAMP2/Iw was higher than that in SAMR1/Iw (p<0.001). However, in all 12-month old SAM/Iw, whether SAMP2/Iw or SAMR1/Iw, the D/L ratio was higher in males than in females. There were minor differences in the age-related changes in the D/L ratios between different types of cranial bone. In 1-month old SAM/Iw the rectal temperature was similar in both males and females. However from the age of 2 months, there was a divergence, with the rectal temperature measurement in SAMP2/Iw reaching a peak 2 months of age, whereas SAMR1/Iw had the highest temperature readings at 6 months of age. In both SAMP2/Iw older than 2 months, and SAMR1/Iw older than 6 months, the temperature readings tended to gradually decrease with age in both males and females. These results suggest that the differences in D/L-aspartic acid ratios were dependent on the age, gender, and strain of SAM/Iw, but were not dependant on the type of cranial bone studied. It seems likely that these differences may be related mainly to changes in body temperature.