[Termination of mid- and late-term gestation with small dose of genkwaninol and rivanol: comparative clinical and pathological analysis].

This paper deals with a comparative study on the clinical aspects of 300 case of mid-late-term abortions induced by small dose and routine dose of alcoholic extract of Flos Genkwa and by rivanol and on 100 cases of fetal autopsies. Clinical aspects of 300 cases of abortions, the therapeutic effective rate, and the fetal mortality rate of the small doses of Flos Genkwa are similar to those of the routine doses of Flos Genkwa but with fewer side effects. As compared with the rivanol group, lower the time of induction of abortion is shorter, the rate of live fetuses and the cases with retention of part of the membranes and placenta are fewer. Pathologic aspects of 100 cases of fetal autopsies -- the predominant pathologic changes of the fetus in the Flos Genkwa group are congestion and hemorrhage in contrast with edema in the rivanol group. Degeneration and necrosis in visceral organs occurred in both groups, but they were severe in the Flos Genkwa group. The predominant pathologic changes of umbilical cord in the Flos Genkwa group were trauma and proliferation of intima, thrombosis, and pan-vesselitis. In the rivanol group, the predominant changes were diffuse infiltration of macrophages in the stroma. In both groups there was degeneration and necrosis of trophoblasts of placenta. In Flos Genkwa group, the vessels in the chorionic villi were highly contracted, even the lumen were closed, while in the rivanol group the vessels were dilated. The inflammation of placentas and decidua and the degeneration and necrosis of decidua were also thoroughly examined, analyzed, and compared.