[皮肤受累是b细胞淋巴细胞白血病/淋巴瘤的表现形式]。

Anales Espanoles De Pediatria Pub Date : 2002-12-01
R López Almaraz, J M feminine Raya Sánchez, M Domínguez Suárez, M feminine L Brito Barroso Mf, J Rodríguez Luis
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引用次数: 0

摘要

原发性皮肤受累的b细胞淋巴细胞白血病/淋巴瘤在儿童中是罕见的。我们报告一个11岁半的女孩,在转介到我们中心的5个月前,接受了手术切除一个小的臀部肿瘤,组织病理学诊断为淋巴细胞增生提示大细胞淋巴瘤。在检查中,在先前切除肿瘤的疤痕附近观察到小淋巴结的存在。血象示白细胞2.7 × 9/l,中性粒细胞0.5 × 9/l;其余系列和补充检查均正常。骨髓穿刺显示52%的母细胞具有常见(b细胞)急性淋巴细胞白血病L2亚型(FAB)的免疫表型和形态学特征。在完成多次化疗10个月后,患者现已完全缓解。我们想强调的是,一个小的生长缓慢的皮肤淋巴结可能是淋巴母细胞淋巴瘤或急性淋巴母细胞白血病的表现形式。
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[Cutaneous involvement as the form of presentation in B-cell lymphoblastic leukemia/lymphoma].

Primary cutaneous involvement in B-cell lymphoblastic leukemia/lymphoma is rare in childhood. We present the case of an eleven and a half year old girl who, five months prior to being referred to our center, had undergone surgery to remove a small gluteal tumor diagnosed histopathologically as lymphoid proliferation suggestive of large cell lymphoma. On examination the presence of small nodes close to the scar where the tumor had previously been removed was observed. Hemogram revealed 2.7 x 9/l white blood cells with 0.5 x 9/l neutrophils; the remaining series and complementary investigations were normal. Bone marrow aspiration revealed 52 % blastic cells with immunophenotype and morphological characteristics of common (B-cell) acute lymphoblastic leukemia with L2 subtype in the French-American-British (FAB) classification. Ten months after finishing polychemotherapy, the patient is now in complete remission. We would like to highlight that a small slow-growing cutaneous node could be the presenting form of lymphoblastic lymphoma or acute lymphoblastic leukemia.

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