作为保护性植物化学物质储存库的印度药用植物。

Saroj Arora, Kamaljit Kaur, Swayamjot Kaur
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引用次数: 129

摘要

印度是世界上12个生物多样性大国之一,因此保护和可持续利用其生物多样性资源对印度至关重要。植物次生代谢物由于其药理意义,长期以来一直受到人们的关注。有鉴于此,我们测试了金合欢、nilotica、核桃的树皮粉,以及已知富含多酚的Terminalia bellerica、T. chebula、Emblica officinalis的果实粉和一种复方药物“Triphala”的抗诱变活性。采用框架移位诱变试验菌株TA98和碱基对置换菌株TA100对直接作用诱变剂(NPD、叠氮化钠)和s9依赖性诱变剂2-氨基芴(2AF)的抗诱变活性进行平板掺入Ames沙门氏菌组氨酸还原试验。所有植物的丙酮提取物均表现出显著的抗诱变活性,但阿拉伯相思的丙酮提取物表现出显著的抗诱变作用。此外,该制剂对TA98和TA100鼠伤寒沙门菌间接作用诱变剂2AF的抑制效果均优于直接作用诱变剂。结果表明,所研究的药用植物树皮和果实的丙酮提取物中含有具有抗诱变/抗癌潜力的成分,值得进一步研究。
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Indian medicinal plants as a reservoir of protective phytochemicals.

India is one of the 12 mega diversity countries in the world so it has a vital stake in conservation and sustainable utilization of its biodiversity resources. Plant secondary metabolites have been of interest to man for a long time due to their pharmacological relevance. With this in view, the bark powder of Acacia auriculiformis, A. nilotica, Juglans regia, and the fruit powder of Terminalia bellerica, T. chebula, Emblica officinalis, and a combination drug "Triphala," which are known to be rich in polyphenols, were tested for their antimutagenic activities. Antimutagenic activities of the extracts were estimated by employing the plate incorporation Ames Salmonella histidine reversion assay by using the frame shift mutagen tester strain TA98 and base pair substitution strain TA100 against direct acting mutagens (NPD, sodium azide), and the S9-dependent mutagen 2-aminofluorene(2AF). Acetone extracts of all the plants exhibited significant antimutagenic activities among the other extracts tested, but an acetone extract of Acacia nilotica showed a marked anti-mutagent effect. Furthermore, it was more effective against indirect acting mutagen, 2AF, in both TA98 and TA100 tester strains of Salmonella typhimurium than against the direct acting mutagens. The results indicate that an acetone extract of bark and fruit of the medicinal plants under study harbors constituents with promising antimutagenic/anticarcinogenic potential that could be investigated further.

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