托吡酯对脑电图的定量影响。

Clinical EEG (electroencephalography) Pub Date : 2003-04-01 DOI:10.1177/155005940303400208

W W Wang, J C Li, X Wu

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引用次数: 12

摘要

目的:应用定量药物脑电图(QPEEG)研究托吡酯(TPM)对脑电图的影响。方法:对癫痫患者和健康成人分别给予1剂TPM。在给药前和给药后24小时内定期采集脑电图样本。对脑电活动进行功率谱分析。结果:给药后慢波功率、α 1波段功率和总功率均增加，双枕区慢波功率增加，头皮各区域总功率增加。在θ波段和α 1波段(健康成人)或δ波段和θ波段(患者)的功率百分比增加。结论:TPM可改变脑电背景活动。这些变化不同于其他抗癫痫药物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Quantitative EEG effects of topiramate.

Objective: The study is to invesigate the effect of topiramate (TPM) on EEG by means of quantitative pharmacoelectroencephalography (QPEEG).

Methods: One dose of TPM was administrated to epileptics and healthy adults. The EEG samples were obtained prior to and at regular intervals within the 24 hours following the administration of TPM. The EEG activity was processed with power spectral analysis.

Results: The power of slow wave, alpha 1 bands and total power increased after the administration of TPM, the power or slow wave in both occipital areas, and the total power of all scalp areas also increased. The percent of power increased at the theta band and alpha 1 band (healthy adults) or delta band, theta band (patients).

Conclusion: TPM can change the EEG background activity. These changes are different from other antiepileptic drugs.

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