放射性标记nf - κ B功能抑制剂去羟甲基环氧喹诺霉素的制备。

Drugs under experimental and clinical research Pub Date : 2003-01-01

C Chaicharoenpong, K Kato, K Umezawa

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引用次数: 0

摘要

Dehydroxymethylepoxyquinomicin (DHMEQ)是环氧喹诺霉素C的合成衍生物，在培养细胞中是一种有效的特异性nf - κ B抑制剂。以硼氚钠为原料合成了氚标记的DHMEQ。合成的氚标记DHMEQ的比放射性为15.45 mCi/mmol。该化合物可用于研究DHMEQ的作用机理和稳定性。

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Preparation of radioactively labeled dehydroxymethyl-epoxyquinomicin, an NF-kappa B function inhibitor.

Dehydroxymethylepoxyquinomicin (DHMEQ), a synthetic derivative of epoxyquinomicin C, is a potent and specific inhibitor of NF-kappa B in cultured cells. Tritium-labeled DHMEQ was synthesized with sodium borotritium. Specific radioactivity of the synthesized tritium-labeled DHMEQ was 15.45 mCi/mmol. This compound would be for the study of the mechanism of action and the stability of DHMEQ.

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Drugs under experimental and clinical research

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