{"title":"间期和分裂核的去氧核糖核酸。","authors":"C E STEVENS, R DAOUST, C P LEBLOND","doi":"10.1139/cjms53-027","DOIUrl":null,"url":null,"abstract":"Classical genetics has associated the rigid transmission of hereditary characters with the constancy of the chromosome pattern. Modern work has shown that the chromosomes contain the substance desoxyribonucleic acid (DNA), which is believed to be the carrier of genetic potential. In general, the amount of this material present per cell is constant in all organs and tissues in a given species. Furthermore, isotopic work with a DNA precursor, phosphorus, showed that it does not enter the DNA of tissues in which the cells do not divide—a result interpreted as supporting the classical concept of the stability of genetic material. It was known, on the other hand, that phosphorus is incorporated into the DNA of tissues containing cells undergoing division—a result interpreted as being due to the synthesis of DNA associated with cell division. Evidence is presented to indicate that such synthesis does occur, but is far more extensive than was hitherto suspected, since it involves the complete replacement of all ...","PeriodicalId":86015,"journal":{"name":"Canadian journal of medical sciences","volume":"31 3","pages":"263-78"},"PeriodicalIF":0.0000,"publicationDate":"1953-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1139/cjms53-027","citationCount":"7","resultStr":"{\"title\":\"The desoxyribonucleic acid of interphase and dividing nuclei.\",\"authors\":\"C E STEVENS, R DAOUST, C P LEBLOND\",\"doi\":\"10.1139/cjms53-027\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Classical genetics has associated the rigid transmission of hereditary characters with the constancy of the chromosome pattern. Modern work has shown that the chromosomes contain the substance desoxyribonucleic acid (DNA), which is believed to be the carrier of genetic potential. In general, the amount of this material present per cell is constant in all organs and tissues in a given species. Furthermore, isotopic work with a DNA precursor, phosphorus, showed that it does not enter the DNA of tissues in which the cells do not divide—a result interpreted as supporting the classical concept of the stability of genetic material. It was known, on the other hand, that phosphorus is incorporated into the DNA of tissues containing cells undergoing division—a result interpreted as being due to the synthesis of DNA associated with cell division. Evidence is presented to indicate that such synthesis does occur, but is far more extensive than was hitherto suspected, since it involves the complete replacement of all ...\",\"PeriodicalId\":86015,\"journal\":{\"name\":\"Canadian journal of medical sciences\",\"volume\":\"31 3\",\"pages\":\"263-78\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1953-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1139/cjms53-027\",\"citationCount\":\"7\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Canadian journal of medical sciences\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1139/cjms53-027\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Canadian journal of medical sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1139/cjms53-027","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The desoxyribonucleic acid of interphase and dividing nuclei.
Classical genetics has associated the rigid transmission of hereditary characters with the constancy of the chromosome pattern. Modern work has shown that the chromosomes contain the substance desoxyribonucleic acid (DNA), which is believed to be the carrier of genetic potential. In general, the amount of this material present per cell is constant in all organs and tissues in a given species. Furthermore, isotopic work with a DNA precursor, phosphorus, showed that it does not enter the DNA of tissues in which the cells do not divide—a result interpreted as supporting the classical concept of the stability of genetic material. It was known, on the other hand, that phosphorus is incorporated into the DNA of tissues containing cells undergoing division—a result interpreted as being due to the synthesis of DNA associated with cell division. Evidence is presented to indicate that such synthesis does occur, but is far more extensive than was hitherto suspected, since it involves the complete replacement of all ...