再生大鼠肝脏中尿嘧啶降解酶的延迟合成

Per Fritzson
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引用次数: 12

摘要

1.1. 在幼龄大鼠和具有不同能力的大鼠肝脏中测定了尿嘧啶降解酶的水平。研究发现,肝脏的生长或肝脏将尿嘧啶纳入核酸的能力的增强与尿嘧啶降解酶水平的降低并不一定相关。二氢尿嘧啶脱氢酶(4,5二氢尿嘧啶:NADP氧化还原酶,EC 1.3.1.2)的合成速率已经根据再生大鼠肝脏的生长数据和酶值计算出来,并且已经证明,肝脏再生过程中二氢尿嘧啶脱氢酶活性的下降可以通过假设肝脏生长开始后酶的合成延迟24小时来充分解释。由此可见,尿嘧啶降解活性的降低与肝脏生长的启动无关。对再生大鼠肝脏中二氢尿嘧啶脱氢酶合成的控制因素进行了研究。
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Delayed synthesis of uracil-degrading enzymes in regenerating rat liver

  • 1.

    1. The levels of the uracil-degrading enzymes have been determined in livers from young rats and from rats with different capacity to incorporate uracil into liver RNA. It was found that liver growth or increased ability of the liver to incorporate uracil into the nucleic acids was not necessarily associated with decreased levels of the uracil-degrading enzymes.

  • 2.

    2. The rate of synthesis of dihydrouracil dehydrogenase (4,5 dihydrouracil: NADP oxidoreductase, EC 1.3.1.2) has been calculated from growth data and enzyme values from studies of regenerating rat liver, and it has been shown that the decrease which occurs in dihydrouracil dehydrogenase activity during liver regeneration can be adequately explained by assuming a 24-h delay of the synthesis of the enzyme after initiation of liver growth. It is concluded that a decrease in uracil-degrading activity is not involved in the initiation of liver growth.

  • 3.

    3. Some factors which could possibly control the synthesis of dihydrouracil dehydrogenase in regenerating rat liver have been examined.

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Author index Erratum Subject index Changes in sedimentation properties of ribosomal ribonucleic acids during the course of ribosome formation in Escherichia coli The inhibition of deoxyribonucleotidyl transferase, DNAase and RNAase by sodium poly ethenesulfonic acid. Effect of the molecular weight of the inhibitor
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