[球囊闭塞逆行经静脉封堵术在胃静脉曲张出血中的临床应用]。

Eun Soo Kim, Soo Young Park, Ki Tae Kwon, Dong Seok Lee, Min Jae Park, In Kwon Chung, Jin Hyung Park, Chang Min Cho, Won Young Tak, Young Oh Kweon, Sung Kook Kim, Yong Whan Choi, Chang Kyu Seong
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引用次数: 0

摘要

背景/目的:胃静脉曲张出血很难在内镜下治疗,因为胃静脉曲张的血流动力学与食管静脉曲张不同。经颈静脉肝内门静脉系统分流术(TIPS)虽应用广泛,但并不一定能使胃静脉曲张消退,反而可能加重肝性脑病。球囊闭塞逆行经静脉闭塞术(BRTO)是一种微创治疗胃静脉曲张出血的新方法。本研究的目的是评估BRTO作为胃静脉曲张出血的新治疗方案的治疗效果和随访并发症。方法:选取2001年9月至2003年4月接受BRTO治疗的胃静脉曲张出血患者为研究对象。经腹部CT明确确认分流后,经胃肾分流闭塞时,将硬化剂5%油酸乙醇胺注入胃静脉曲张。在随访期间(6-23个月,平均17.7个月),当观察到硬化剂的凝血无渗漏时,该手术被认为是技术上的成功,当出血停止,静脉曲张缩小或根除时,该手术被认为是临床上的成功。结果:13例胃静脉曲张出血患者中12例(92%)技术成功。没有明显的副作用。在一例失败的病例中,使用TIPS控制出血。在12名技术上成功的患者中,有11名在临床上取得了成功。后续内镜检查显示4例患者原有食管静脉曲张加重,2例患者食管静脉曲张新发。内镜下静脉曲张结扎术是在一个病人食管静脉曲张出血在随访期间。结论:与TIPS相比,BRTO是一种可行、安全、微创的手术,是治疗胃静脉曲张出血的有效方法。考虑到原有食管静脉曲张可能加重或新发食管静脉曲张,随访期间可能需要定期内镜检查。
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[The clinical usefulness of balloon occluded retrograde transvenous obliteration in gastric variceal bleeding].

Background/aims: Gastric variceal bleeding is difficult to treat endoscopically because the hemodynamics of the gastric varix are different from that of the esophageal varix. Transjugular intrahepatic portosystemic shunt (TIPS), which has been used widely, does not always result in the regression of gastric varix and it may aggravate the hepatic encephalopathy. Balloon occluded retrograde transvenous obliteration (BRTO) was introduced as a new procedure for gastric variceal bleeding with minimal invasiveness. The purpose of this study was to evaluate the therapeutic effects and complications on follow-up of BRTO as a new treatment option for gastric variceal bleeding.

Methods: Patients with gastric variceal bleeding, who were treated with BRTO form September, 2001 to April, 2003, were included in the study. After the definite confirmation of the shunts with abdominal CT, the sclerosing agent, 5% ethanolamine oleate, was injected into the gastric varix during occlusion through gastrorenal shunts. The procedure was deemed a technical success when the clotting of the sclerosing agent was observed without leakage, and a clinical success when bleeding stopped and the varix decreased in size or was eradicated during the follow-up period (6-23 months, mean: 17.7).

Results: Technical success was achieved in 12 of 13 patients (92%) with gastric variceal bleeding. There were no significant side effects. In the one case of failure, the bleeding was controlled with TIPS. Eleven of the 12 patients who had technical success were shown to be clinically successful. The follow-up endoscopic exam showed some aggravation of pre-existing esophageal varices in four patients and a new development of esophageal varices in two patients. Endoscopic variceal ligation was done on one patient in whom esophageal variceal bleeding was present during the follow-up period.

Conclusions: BRTO was proven to be a feasible, safe and less invasive procedure than TIPS and found to be an effective treatment of a gastric variceal bleeding. Considering the possible aggravation of pre-existing esophageal varices or the new development of esophageal varices, regular endoscopic examinations might be needed during the follow-up period.

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