Narendra K. Bairwa, Dheeraj Malhotra, Anjana Saha, R. Bamezai
{"title":"印度人群KRTHB6基因新的启动子多态性(-71C>T","authors":"Narendra K. Bairwa, Dheeraj Malhotra, Anjana Saha, R. Bamezai","doi":"10.1016/j.anngen.2004.02.006","DOIUrl":null,"url":null,"abstract":"<div><p>We have screened the basal promoter region, of KRTHB6 gene involving CAAT and TATA boxes in randomly selected 125 individuals of Indian origin by PCR-SSCP and DNA sequencing. We observed a novel promoter polymorphism (-71C>T) which could be differentiated by using <em>LweI</em> restriction enzyme. The frequency of –71 C allele, allele A (Accession no AY203963), was observed to be higher ( 0.712) in comparison to –71 T allele, allele B (0.288) (Accession no. AY037552).</p></div>","PeriodicalId":100089,"journal":{"name":"Annales de Génétique","volume":"47 2","pages":"Pages 125-127"},"PeriodicalIF":0.0000,"publicationDate":"2004-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.anngen.2004.02.006","citationCount":"1","resultStr":"{\"title\":\"A novel promoter polymorphism (-71C>T) in KRTHB6 gene in Indian population\",\"authors\":\"Narendra K. Bairwa, Dheeraj Malhotra, Anjana Saha, R. Bamezai\",\"doi\":\"10.1016/j.anngen.2004.02.006\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>We have screened the basal promoter region, of KRTHB6 gene involving CAAT and TATA boxes in randomly selected 125 individuals of Indian origin by PCR-SSCP and DNA sequencing. We observed a novel promoter polymorphism (-71C>T) which could be differentiated by using <em>LweI</em> restriction enzyme. The frequency of –71 C allele, allele A (Accession no AY203963), was observed to be higher ( 0.712) in comparison to –71 T allele, allele B (0.288) (Accession no. AY037552).</p></div>\",\"PeriodicalId\":100089,\"journal\":{\"name\":\"Annales de Génétique\",\"volume\":\"47 2\",\"pages\":\"Pages 125-127\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2004-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.anngen.2004.02.006\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Annales de Génétique\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0003399504000103\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annales de Génétique","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0003399504000103","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
摘要
我们通过PCR-SSCP和DNA测序，在随机选择的125名印度裔个体中筛选了KRTHB6基因涉及CAAT和TATA盒子的基础启动子区域。我们发现了一个新的启动子多态性(-71C>T)，可以用LweI限制性内切酶来区分。-71 C等位基因A (Accession no AY203963)的频率为0.712，高于-71 T等位基因B (Accession no AY203963)的频率(0.288)。AY037552)。
A novel promoter polymorphism (-71C>T) in KRTHB6 gene in Indian population
We have screened the basal promoter region, of KRTHB6 gene involving CAAT and TATA boxes in randomly selected 125 individuals of Indian origin by PCR-SSCP and DNA sequencing. We observed a novel promoter polymorphism (-71C>T) which could be differentiated by using LweI restriction enzyme. The frequency of –71 C allele, allele A (Accession no AY203963), was observed to be higher ( 0.712) in comparison to –71 T allele, allele B (0.288) (Accession no. AY037552).
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
