Narendra K. Bairwa, Dheeraj Malhotra, Anjana Saha, R. Bamezai
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引用次数: 1
摘要
我们通过PCR-SSCP和DNA测序，在随机选择的125名印度裔个体中筛选了KRTHB6基因涉及CAAT和TATA盒子的基础启动子区域。我们发现了一个新的启动子多态性(-71C>T)，可以用LweI限制性内切酶来区分。-71 C等位基因A (Accession no AY203963)的频率为0.712，高于-71 T等位基因B (Accession no AY203963)的频率(0.288)。AY037552)。
A novel promoter polymorphism (-71C>T) in KRTHB6 gene in Indian population
We have screened the basal promoter region, of KRTHB6 gene involving CAAT and TATA boxes in randomly selected 125 individuals of Indian origin by PCR-SSCP and DNA sequencing. We observed a novel promoter polymorphism (-71C>T) which could be differentiated by using LweI restriction enzyme. The frequency of –71 C allele, allele A (Accession no AY203963), was observed to be higher ( 0.712) in comparison to –71 T allele, allele B (0.288) (Accession no. AY037552).
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