{"title":"钒酸盐对小鼠葡萄糖激酶和己糖激酶活性的影响。","authors":"Ming-zhi Xu, Ai-zhen Zhang, Xiang-rong Li, Wei Xu, Ling-wei Shen","doi":"10.1631/jzus.2004.1245","DOIUrl":null,"url":null,"abstract":"<p><p>This study aimed at acquiring knowledge on the hypoglycemic mechanisms of sodium metavanadate (SMV) showed that the liver glucokinase and muscle hexokinase activities increased rapidly after oral SMV was given, and that the blood glucose level was correlated closely with the activities of the two enzymes but not with the insulin level; which indicated that SMV could improve the altered glucose phosphorylation in diabetic mice independently of stimulating insulin secretion. This was probably one of the mechanisms of hypoglycemic effects of SMV.</p>","PeriodicalId":85042,"journal":{"name":"Journal of Zhejiang University. Science","volume":"5 10","pages":"1245-8"},"PeriodicalIF":0.0000,"publicationDate":"2004-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1631/jzus.2004.1245","citationCount":"8","resultStr":"{\"title\":\"Effects of vanadate on the activities of mice glucokinase and hexokinase.\",\"authors\":\"Ming-zhi Xu, Ai-zhen Zhang, Xiang-rong Li, Wei Xu, Ling-wei Shen\",\"doi\":\"10.1631/jzus.2004.1245\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>This study aimed at acquiring knowledge on the hypoglycemic mechanisms of sodium metavanadate (SMV) showed that the liver glucokinase and muscle hexokinase activities increased rapidly after oral SMV was given, and that the blood glucose level was correlated closely with the activities of the two enzymes but not with the insulin level; which indicated that SMV could improve the altered glucose phosphorylation in diabetic mice independently of stimulating insulin secretion. This was probably one of the mechanisms of hypoglycemic effects of SMV.</p>\",\"PeriodicalId\":85042,\"journal\":{\"name\":\"Journal of Zhejiang University. Science\",\"volume\":\"5 10\",\"pages\":\"1245-8\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2004-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1631/jzus.2004.1245\",\"citationCount\":\"8\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Zhejiang University. Science\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1631/jzus.2004.1245\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Zhejiang University. Science","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1631/jzus.2004.1245","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Effects of vanadate on the activities of mice glucokinase and hexokinase.
This study aimed at acquiring knowledge on the hypoglycemic mechanisms of sodium metavanadate (SMV) showed that the liver glucokinase and muscle hexokinase activities increased rapidly after oral SMV was given, and that the blood glucose level was correlated closely with the activities of the two enzymes but not with the insulin level; which indicated that SMV could improve the altered glucose phosphorylation in diabetic mice independently of stimulating insulin secretion. This was probably one of the mechanisms of hypoglycemic effects of SMV.
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