抗cd20单克隆抗体治疗SLE。

Current directions in autoimmunity Pub Date : 2005-01-01 DOI:10.1159/000082104

R John Looney, Jennifer Anolik, Iñaki Sanz

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引用次数: 48

摘要

系统性红斑狼疮(SLE)是一种累及多器官系统的自身免疫性疾病，以抗核抗体为特征。虽然T细胞和树突状细胞可能在SLE中起主要作用，但一些证据强烈表明B细胞起核心作用。本文将回顾B细胞在人类SLE中的作用，以及目前可用的抗cd20(利妥昔单抗)消耗B细胞治疗SLE的数据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Treatment of SLE with anti-CD20 monoclonal antibody.

Systemic lupus erythemaotsus (SLE) is an autoimmune disease involving multiple organ systems and characterized by anti-nuclear antibodies. While T cells and dendritic cells may play major roles in SLE, several lines of evidence strongly suggest a central role for B cells. This article will review the role of B cells in human SLE as well as the currently available data on the treatment of SLE by depleting B cells with anti-CD20 (rituximab).

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Current directions in autoimmunity

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