Aline Receveur , Jeanne Ong , Laurent Merlin , Zahia Azgui , Hélène Merle-Béral , Roland Berger , Florence Nguyen-Khac
{"title":"急性髓母细胞白血病中与双分钟染色体和MYC扩增相关的4三体","authors":"Aline Receveur , Jeanne Ong , Laurent Merlin , Zahia Azgui , Hélène Merle-Béral , Roland Berger , Florence Nguyen-Khac","doi":"10.1016/j.anngen.2004.08.004","DOIUrl":null,"url":null,"abstract":"<div><p>A case of de novo acute myeloblastic leukemia (AML) M2, with trisomy 4 and double minute (dmin) chromosomes is reported. Amplification of the <em>MYC</em> gene ascertained by FISH was associated with dmin. A review of the literature of trisomy 4-dmin-associated AML shows that this entity preferentially occurs in elderly women and is not always associated with previously identified exposition to mutagens.</p></div>","PeriodicalId":100089,"journal":{"name":"Annales de Génétique","volume":"47 4","pages":"Pages 423-427"},"PeriodicalIF":0.0000,"publicationDate":"2004-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.anngen.2004.08.004","citationCount":"12","resultStr":"{\"title\":\"Trisomy 4 associated with double minute chromosomes and MYC amplification in acute myeloblastic leukemia\",\"authors\":\"Aline Receveur , Jeanne Ong , Laurent Merlin , Zahia Azgui , Hélène Merle-Béral , Roland Berger , Florence Nguyen-Khac\",\"doi\":\"10.1016/j.anngen.2004.08.004\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>A case of de novo acute myeloblastic leukemia (AML) M2, with trisomy 4 and double minute (dmin) chromosomes is reported. Amplification of the <em>MYC</em> gene ascertained by FISH was associated with dmin. A review of the literature of trisomy 4-dmin-associated AML shows that this entity preferentially occurs in elderly women and is not always associated with previously identified exposition to mutagens.</p></div>\",\"PeriodicalId\":100089,\"journal\":{\"name\":\"Annales de Génétique\",\"volume\":\"47 4\",\"pages\":\"Pages 423-427\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2004-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.anngen.2004.08.004\",\"citationCount\":\"12\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Annales de Génétique\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0003399504000784\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annales de Génétique","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0003399504000784","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Trisomy 4 associated with double minute chromosomes and MYC amplification in acute myeloblastic leukemia
A case of de novo acute myeloblastic leukemia (AML) M2, with trisomy 4 and double minute (dmin) chromosomes is reported. Amplification of the MYC gene ascertained by FISH was associated with dmin. A review of the literature of trisomy 4-dmin-associated AML shows that this entity preferentially occurs in elderly women and is not always associated with previously identified exposition to mutagens.
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