{"title":"新型苯基支链环丙基核苷的合成及抗hiv活性研究","authors":"Ying Wu, Joon Hee Hong","doi":"10.1016/j.farmac.2005.06.011","DOIUrl":null,"url":null,"abstract":"<div><p><span>Novel phenyl branched cyclopropyl nucleoside analogues were designed and synthesized as potential antiviral agents. Cyclopropanation was performed via classical Simmons–Smith reaction using Zn(Et)</span><sub>2</sub> and CH<sub>2</sub>I<sub>2</sub><span>. Coupling of the mesylates </span><strong>11</strong> and <strong>12</strong><span> with natural bases (A,C,T,U) and desilylation afforded a series of novel cyclopropyl nucleosides </span><strong>21</strong>–<strong>28</strong><span>. The synthesized compounds were evaluated for their antiviral and antitumor activity against various viruses such as HIV, HSV-1, HSV-2 and HCMV.</span></p></div>","PeriodicalId":77128,"journal":{"name":"Farmaco (Societa chimica italiana : 1989)","volume":"60 9","pages":"Pages 739-744"},"PeriodicalIF":0.0000,"publicationDate":"2005-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.farmac.2005.06.011","citationCount":"6","resultStr":"{\"title\":\"Synthesis and anti-HIV activity of novel phenyl branched cyclopropyl nucleosides\",\"authors\":\"Ying Wu, Joon Hee Hong\",\"doi\":\"10.1016/j.farmac.2005.06.011\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><span>Novel phenyl branched cyclopropyl nucleoside analogues were designed and synthesized as potential antiviral agents. Cyclopropanation was performed via classical Simmons–Smith reaction using Zn(Et)</span><sub>2</sub> and CH<sub>2</sub>I<sub>2</sub><span>. Coupling of the mesylates </span><strong>11</strong> and <strong>12</strong><span> with natural bases (A,C,T,U) and desilylation afforded a series of novel cyclopropyl nucleosides </span><strong>21</strong>–<strong>28</strong><span>. The synthesized compounds were evaluated for their antiviral and antitumor activity against various viruses such as HIV, HSV-1, HSV-2 and HCMV.</span></p></div>\",\"PeriodicalId\":77128,\"journal\":{\"name\":\"Farmaco (Societa chimica italiana : 1989)\",\"volume\":\"60 9\",\"pages\":\"Pages 739-744\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2005-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.farmac.2005.06.011\",\"citationCount\":\"6\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Farmaco (Societa chimica italiana : 1989)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0014827X05001448\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Farmaco (Societa chimica italiana : 1989)","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0014827X05001448","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Synthesis and anti-HIV activity of novel phenyl branched cyclopropyl nucleosides
Novel phenyl branched cyclopropyl nucleoside analogues were designed and synthesized as potential antiviral agents. Cyclopropanation was performed via classical Simmons–Smith reaction using Zn(Et)2 and CH2I2. Coupling of the mesylates 11 and 12 with natural bases (A,C,T,U) and desilylation afforded a series of novel cyclopropyl nucleosides 21–28. The synthesized compounds were evaluated for their antiviral and antitumor activity against various viruses such as HIV, HSV-1, HSV-2 and HCMV.
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