一类类似类胡萝卜素的新型多不饱和线性醛类parrodienes的生物活性。

E Pini, A Bertelli, R Stradi, M Falchi
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引用次数: 0

摘要

一种名为parrodiene的新化学物质已经从鹦鹉的羽毛中提取出来。从化学的角度来看,parrodi烯是一种类似于类胡萝卜素的多不饱和醛。基于这种相似性,我们组织了一些生物学实验来评估CCl4对细胞膜脂质过氧化的抑制作用、对紫外线的保护作用、抗炎活性和对鸟氨酸脱羧酶增加的保护作用,作为肿瘤皮肤改变的标志。这些实验结果表明,不饱和二烯(parrodiene)在抑制和预防许多生物过程中起着重要作用,这些生物过程是不同病理疾病的基础。
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Biological activity of parrodienes, a new class of polyunsaturated linear aldehydes similar to carotenoids.

A new chemical named parrodienes has been extracted from parrots' plumage. From the chemical point of view, parrodienes are polyunsaturated aldehydes similar to carotenoids. On the basis of this similarity we organized some biological experiments to evaluate the inhibition of lipoperoxidation of cell membranes induced by CCl4, protection against ultraviolet rays, anti-inflammatory activity and protection from an increase of ornithine-decarboxylase as marker of tumoral skin alteration. The results of these experiments showed that unsaturated dienes (parrodienes) play an important role on the inhibition and prevention of many biological processes that are at the basis of different pathological disorders.

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