Quanjiang Dong , Maria O’Sullivan , Abdurrazag Nami , Paul Dowling , Gwen Murphy , Martin Buckley , Colm O’Morain
{"title":"幽门螺杆菌基因位点与胃肠化生呈负相关","authors":"Quanjiang Dong , Maria O’Sullivan , Abdurrazag Nami , Paul Dowling , Gwen Murphy , Martin Buckley , Colm O’Morain","doi":"10.1016/j.femsim.2005.02.003","DOIUrl":null,"url":null,"abstract":"<div><p>The genomic contents of <span><span>Helicobacter pylori</span></span><span><span><span> strain C1 from a patient with gastric cancer and strain 98587 from a patient with duodenal ulcer disease were compared using a rapid </span>subtractive hybridisation approach. A total of 11 tester-specific sequences representing gene specificity, DNA rearrangement and sequence variation were identified. This included two novel sequences, clone </span>P32 and clone F5, which have no significant homologue in the database. </span><em>H. pylori</em><span> strains positive for clone P32 were less prevalent in patients with gastric intestinal metaplasia (12.5%) than in duodenal ulcer (39.1%) (</span><em>p</em>\n<!--> <!-->=<!--> <span>0.036), or chronic gastritis (38.1%) (</span><em>p</em>\n<!--> <!-->=<!--> <!-->0.036). The results suggest that <em>H. pylori</em> clone P32 is potentially a useful marker for distinguishing intestinal metaplasia associated strains from others.</p></div>","PeriodicalId":12220,"journal":{"name":"FEMS immunology and medical microbiology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2005-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.femsim.2005.02.003","citationCount":"2","resultStr":"{\"title\":\"A genetic locus of Helicobacter pylori inversely associated with gastric intestinal metaplasia\",\"authors\":\"Quanjiang Dong , Maria O’Sullivan , Abdurrazag Nami , Paul Dowling , Gwen Murphy , Martin Buckley , Colm O’Morain\",\"doi\":\"10.1016/j.femsim.2005.02.003\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The genomic contents of <span><span>Helicobacter pylori</span></span><span><span><span> strain C1 from a patient with gastric cancer and strain 98587 from a patient with duodenal ulcer disease were compared using a rapid </span>subtractive hybridisation approach. A total of 11 tester-specific sequences representing gene specificity, DNA rearrangement and sequence variation were identified. This included two novel sequences, clone </span>P32 and clone F5, which have no significant homologue in the database. </span><em>H. pylori</em><span> strains positive for clone P32 were less prevalent in patients with gastric intestinal metaplasia (12.5%) than in duodenal ulcer (39.1%) (</span><em>p</em>\\n<!--> <!-->=<!--> <span>0.036), or chronic gastritis (38.1%) (</span><em>p</em>\\n<!--> <!-->=<!--> <!-->0.036). The results suggest that <em>H. pylori</em> clone P32 is potentially a useful marker for distinguishing intestinal metaplasia associated strains from others.</p></div>\",\"PeriodicalId\":12220,\"journal\":{\"name\":\"FEMS immunology and medical microbiology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2005-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.femsim.2005.02.003\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"FEMS immunology and medical microbiology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0928824405000477\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"FEMS immunology and medical microbiology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0928824405000477","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
A genetic locus of Helicobacter pylori inversely associated with gastric intestinal metaplasia
The genomic contents of Helicobacter pylori strain C1 from a patient with gastric cancer and strain 98587 from a patient with duodenal ulcer disease were compared using a rapid subtractive hybridisation approach. A total of 11 tester-specific sequences representing gene specificity, DNA rearrangement and sequence variation were identified. This included two novel sequences, clone P32 and clone F5, which have no significant homologue in the database. H. pylori strains positive for clone P32 were less prevalent in patients with gastric intestinal metaplasia (12.5%) than in duodenal ulcer (39.1%) (p
= 0.036), or chronic gastritis (38.1%) (p
= 0.036). The results suggest that H. pylori clone P32 is potentially a useful marker for distinguishing intestinal metaplasia associated strains from others.
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