André L. Santos, Regina M. Takeuchi, Marcela P. Mariotti, Marcelo F. De Oliveira, Maria V.B. Zanoni, Nelson R. Stradiotto
{"title":"玻碳旋转圆盘电极电化学氧化测定阿苯达唑的研究","authors":"André L. Santos, Regina M. Takeuchi, Marcela P. Mariotti, Marcelo F. De Oliveira, Maria V.B. Zanoni, Nelson R. Stradiotto","doi":"10.1016/j.farmac.2005.05.004","DOIUrl":null,"url":null,"abstract":"<div><p><span>In this work, electrochemical oxidation of albendazole (ABZ) was carried out using a glassy carbon-rotating disk electrode. Development of electroanalytical methodology for ABZ quantification in pharmaceutical formulations was also proposed by using linear sweep voltammetric technique. Electrochemical oxidation is observed for ABZ at </span><em>E</em><sub>1/2</sub> <!-->=<!--> <!-->0.99 V vs. Ag/AgCl<sub>sat</sub>, when an anodic wave is observed. Kinetic parameters obtained for ABZ oxidation exhibited a standard heterogeneous rate constant for the electrodic process equal to (1.51<!--> <!-->±<!--> <!-->0.07)<!--> <!-->×<!--> <!-->10<sup>–5</sup> cm s<sup>–1</sup>, with a <em>αn</em><sub>a</sub> value equal to 0.76. Limiting current dependence against ABZ concentration exhibited linearity on 5.0<!--> <!-->×<!--> <!-->10<sup>–5</sup> to 1.0<!--> <!-->×<!--> <!-->10<sup>–2</sup> mol l<sup>–1</sup> range, being obtained a detection limit of 2.4<!--> <!-->×<!--> <!-->10<sup>–5</sup> mol l<sup>–1</sup>. Proposed methodology was applied to ABZ quantification in pharmaceutical formulations.</p></div>","PeriodicalId":77128,"journal":{"name":"Farmaco (Societa chimica italiana : 1989)","volume":"60 8","pages":"Pages 671-674"},"PeriodicalIF":0.0000,"publicationDate":"2005-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.farmac.2005.05.004","citationCount":"18","resultStr":"{\"title\":\"Study of electrochemical oxidation and determination of albendazole using a glassy carbon-rotating disk electrode\",\"authors\":\"André L. Santos, Regina M. Takeuchi, Marcela P. Mariotti, Marcelo F. De Oliveira, Maria V.B. Zanoni, Nelson R. Stradiotto\",\"doi\":\"10.1016/j.farmac.2005.05.004\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><span>In this work, electrochemical oxidation of albendazole (ABZ) was carried out using a glassy carbon-rotating disk electrode. Development of electroanalytical methodology for ABZ quantification in pharmaceutical formulations was also proposed by using linear sweep voltammetric technique. Electrochemical oxidation is observed for ABZ at </span><em>E</em><sub>1/2</sub> <!-->=<!--> <!-->0.99 V vs. Ag/AgCl<sub>sat</sub>, when an anodic wave is observed. Kinetic parameters obtained for ABZ oxidation exhibited a standard heterogeneous rate constant for the electrodic process equal to (1.51<!--> <!-->±<!--> <!-->0.07)<!--> <!-->×<!--> <!-->10<sup>–5</sup> cm s<sup>–1</sup>, with a <em>αn</em><sub>a</sub> value equal to 0.76. Limiting current dependence against ABZ concentration exhibited linearity on 5.0<!--> <!-->×<!--> <!-->10<sup>–5</sup> to 1.0<!--> <!-->×<!--> <!-->10<sup>–2</sup> mol l<sup>–1</sup> range, being obtained a detection limit of 2.4<!--> <!-->×<!--> <!-->10<sup>–5</sup> mol l<sup>–1</sup>. Proposed methodology was applied to ABZ quantification in pharmaceutical formulations.</p></div>\",\"PeriodicalId\":77128,\"journal\":{\"name\":\"Farmaco (Societa chimica italiana : 1989)\",\"volume\":\"60 8\",\"pages\":\"Pages 671-674\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2005-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.farmac.2005.05.004\",\"citationCount\":\"18\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Farmaco (Societa chimica italiana : 1989)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0014827X05001114\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Farmaco (Societa chimica italiana : 1989)","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0014827X05001114","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Study of electrochemical oxidation and determination of albendazole using a glassy carbon-rotating disk electrode
In this work, electrochemical oxidation of albendazole (ABZ) was carried out using a glassy carbon-rotating disk electrode. Development of electroanalytical methodology for ABZ quantification in pharmaceutical formulations was also proposed by using linear sweep voltammetric technique. Electrochemical oxidation is observed for ABZ at E1/2 = 0.99 V vs. Ag/AgClsat, when an anodic wave is observed. Kinetic parameters obtained for ABZ oxidation exhibited a standard heterogeneous rate constant for the electrodic process equal to (1.51 ± 0.07) × 10–5 cm s–1, with a αna value equal to 0.76. Limiting current dependence against ABZ concentration exhibited linearity on 5.0 × 10–5 to 1.0 × 10–2 mol l–1 range, being obtained a detection limit of 2.4 × 10–5 mol l–1. Proposed methodology was applied to ABZ quantification in pharmaceutical formulations.
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