硝苯地平对动脉粥样硬化的保护作用。

S Yamagishi, M Takeuchi
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引用次数: 0

摘要

内皮细胞生长和功能受损被认为是导致动脉粥样硬化发展的初始事件。硝苯地平是目前应用最广泛的以二氢吡啶为基础的钙拮抗剂(DHPs)之一,用于治疗心绞痛和高血压患者。最近,硝苯地平被证明可以改善许多心血管疾病的内皮功能,从而减缓动脉粥样硬化的发生和进展。在这篇综述中,我们讨论硝苯地平的动脉粥样硬化保护作用的分子机制,特别强调其抗氧化特性。
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Atheroprotective properties of nifedipine.

Impaired endothelial cell growth and function have been suggested to be an initial event leading to the development of atherosclerosis. Nifedipine is one of the most widely used dihydropyridine-based calcium antagonists (DHPs) for the treatment of patients with angina and hypertension. Recently, nifedipine was shown to improve endothelial function in many cardiovascular diseases, thus slowing the development and progression of atherosclerosis. In this review, we discuss the molecular mechanisms for the atheroprotective effects of nifedipine, with special emphasis on its anti-oxidative properties.

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