脂质体:生物医学应用。

Chonnam Medical Journal Pub Date : 2021-01-01 Epub Date: 2021-01-25 DOI:10.4068/cmj.2021.57.1.27
Eun-Mi Kim, Hwan-Jeong Jeong
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引用次数: 34

摘要

脂质体以其灵活的物理化学和生物物理特性,作为一种重要的潜在的药物传递系统不断被研究。脂质体通过包封治疗药物克服了传统游离药物治疗的挑战,从而改善了体内生物分布并降低了全身毒性。新的成像模式和解释技术,以及靶向系统配方技术和肿瘤环境信息的新技术,影响了寻找克服传统脂质体配方困难的方法。在这篇综述中,我们简要地讨论了脂质体制剂在生物医学领域的应用,特别是作为一种治疗方法,以及它在未来与诊断和治疗学的新发展相结合时可能发挥的作用。讨论了仍然存在的生物学挑战和翻译障碍。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Liposomes: Biomedical Applications.

Liposomes, with their flexible physicochemical and biophysical properties, continue to be studied as an important potential a critical drug delivery system. Liposomes have overcome the challenges of conventional free drug therapy by encapsulating therapeutic agents, thereby improving in vivo biodistribution and reducing systemic toxicity. New imaging modalities and interpretation techniques, as well as new techniques for targetable system formulation technique, and tumor environmental information, have affected the search for a means of overcoming the difficulties of conventional liposome formulation. In this review, we briefly discuss how liposomal formulation has been applied across the biomedical field, particularly as a therapy, and the role it may play in the future, when paired with new developments in diagnosis and theranostics. The biological challenges that still remain and the translational obstacles are discussed.

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