Red Blood Cell Distribution Width Trajectory During a Multicomponent Exercise in Hospitalized Older Adults: A Secondary Analysis of a Randomized Clinical Trial.

There is emerging evidence that emphasizes RDW as an optimal prognostic biomarker for cardiovascular diseases (Rejuvenation Research: https://pubmed.ncbi.nlm.nih.gov/30572793/ https://pubmed.ncbi.nlm.nih.gov/30132390/). However, there is hardly any evidence of interventions that are capable of modifying RDW. Our aim was to investigate the association of RDW levels and the response to an individualized exercise program in hospitalized older adults. To our knowledge, this is the first study that specifically looks at the impact of an intervention in this parameter among very old hospitalized patients. We have failed to show any change, but we consider that this result is also important in order to continue with the research of the strong correlation of RDW and different biological pathways.