干细胞代谢与饮食

IF 2.3 Q4 CELL & TISSUE ENGINEERING Current Stem Cell Reports Pub Date : 2020-12-01 Epub Date: 2020-10-28 DOI:10.1007/s40778-020-00180-4
Marine Barthez, Zehan Song, Chih Ling Wang, Danica Chen
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引用次数: 0

摘要

审查目的:饮食对健康和长寿有着深远的影响。越来越多的证据表明,饮食会影响组织特异性干细胞的代谢途径,从而影响健康和疾病。在此,我们回顾了几种组织干细胞代谢的异同,并强调了干细胞维持和衰老过程中的线粒体代谢检查点。我们讨论了饮食如何参与营养传感代谢途径并影响干细胞的维持。最后,我们探讨了干细胞饮食和代谢调节的治疗意义:干细胞从静止到增殖的转变与从糖酵解到线粒体OXPHOS的代谢转换有关,线粒体代谢检查点在造血干细胞中受到营养传感器SIRT2、SIRT3和SIRT7的关键控制。肠干细胞在衰老过程中和饮食反应中的稳态主要依赖于脂肪酸代谢和酮体,并受到营养传感器mTOR介导的生态位的影响。阐明干细胞饮食和代谢调控的分子机制为干细胞生物学提供了新的见解,并可能成为逆转干细胞衰老和组织退化的治疗目标。
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Stem Cell Metabolism and Diet.

Purpose of review: Diet has profound impacts on health and longevity. Evidence is emerging to suggest that diet impinges upon the metabolic pathways in tissue-specific stem cells to influence health and disease. Here, we review the similarities and differences in the metabolism of stem cells from several tissues, and highlight the mitochondrial metabolic checkpoint in stem cell maintenance and aging. We discuss how diet engages the nutrient sensing metabolic pathways and impacts stem cell maintenance. Finally, we explore the therapeutic implications of dietary and metabolic regulation of stem cells.

Recent findings: Stem Cell transition from quiescence to proliferation is associated with a metabolic switch from glycolysis to mitochondrial OXPHOS and the mitochondrial metabolic checkpoint is critically controlled by the nutrient sensors SIRT2, SIRT3, and SIRT7 in hematopoietic stem cells. Intestine stem cell homeostasis during aging and in response to diet is critically dependent on fatty acid metabolism and ketone bodies and is influenced by the niche mediated by the nutrient sensor mTOR.

Summary: Nutrient sensing metabolic pathways critically regulate stem cell maintenance during aging and in response to diet. Elucidating the molecular mechanisms underlying dietary and metabolic regulation of stem cells provides novel insights for stem cell biology and may be targeted therapeutically to reverse stem cell aging and tissue degeneration.

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来源期刊
Current Stem Cell Reports
Current Stem Cell Reports Biochemistry, Genetics and Molecular Biology-Genetics
CiteScore
3.30
自引率
0.00%
发文量
19
期刊介绍: The goal of this journal is to publish cutting-edge reviews on subjects pertinent to all aspects of stem cell research, therapy, ethics, commercialization, and policy. We aim to provide incisive, insightful, and balanced contributions from leading experts in each relevant domain that will be of immediate interest to a wide readership of clinicians, basic scientists, and translational investigators. We accomplish this aim by appointing major authorities to serve as Section Editors in key subject areas across the discipline. Section Editors select topics to be reviewed by leading experts who emphasize recent developments and highlight important papers published over the past year on their topics, in a crisp and readable format. We also provide commentaries from well-known figures in the field, and an Editorial Board of internationally diverse members suggests topics of special interest to their country/region and ensures that topics are current and include emerging research.
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