巨细胞病毒复制对宿主线粒体的要求。

IF 3.1 Q2 MICROBIOLOGY Current Clinical Microbiology Reports Pub Date : 2020-12-01 Epub Date: 2020-09-30 DOI:10.1007/s40588-020-00153-5

Chandler H Monk, Kevin J Zwezdaryk

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引用次数: 6

摘要

综述目的:宿主细胞的代谢重组是优化病毒复制所必需的。人类巨细胞病毒(HCMV)已被观察到操纵许多线粒体功能。在这篇综述中，我们描述了HCMV用于控制线粒体功能的不同方面的策略和目标。最近的研究发现:线粒体在满足HCMV复制的生物合成和生物能量需求方面起着重要作用。这是通过改变代谢和信号通路实现的。通过生物发生和裂变/融合动力学介导的形态变化有助于避免细胞死亡，克服氧化应激，最大化线粒体的生物合成和生物能量输出。总结:新出现的数据表明巨细胞病毒依赖于完整的、功能性的宿主线粒体进行最佳复制。HCMV的大尺寸和缓慢的复制动力学使其在复制过程中依赖于线粒体。靶向宿主线粒体是一个很有吸引力的抗病毒靶点。

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Host Mitochondrial Requirements of Cytomegalovirus Replication.

Purpose of review: Metabolic rewiring of the host cell is required for optimal viral replication. Human cytomegalovirus (HCMV) has been observed to manipulate numerous mitochondrial functions. In this review, we describe the strategies and targets HCMV uses to control different aspects of mitochondrial function.

Recent findings: The mitochondria are instrumental in meeting the biosynthetic and bioenergetic needs of HCMV replication. This is achieved through altered metabolism and signaling pathways. Morphological changes mediated through biogenesis and fission/fusion dynamics contribute to strategies to avoid cell death, overcome oxidative stress, and maximize the biosynthetic and bioenergetic outputs of mitochondria.

Summary: Emerging data suggests that cytomegalovirus relies on intact, functional host mitochondria for optimal replication. HCMV large size and slow replication kinetics create a dependency on mitochondria during replication. Targeting the host mitochondria is an attractive antiviral target.

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来源期刊

Current Clinical Microbiology Reports MICROBIOLOGY-

CiteScore

7.50

自引率

1.90%

发文量

期刊介绍： Current Clinical Microbiology Reports commissions expert reviews from leading scientists at the forefront of research in microbiology. The journal covers this broad field by dividing it into four key main areas of study: virology, bacteriology, parasitology, and mycology. Within each of the four sections, experts from around the world address important aspects of clinical microbiology such as immunology, diagnostics, therapeutics, antibiotics and antibiotic resistance, and vaccines. Some of the world’s foremost authorities in the field of microbiology serve as section editors and editorial board members. Section editors select topics for which leading researchers are invited to contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, which are highlighted in annotated reference lists. These timely reviews of the literature examine the latest scientific discoveries and controversies as they emerge and are indispensable to both researchers and clinicians. The editorial board, composed of more than 20 internationally diverse members, reviews the annual table of contents, ensures that topics address all aspects of emerging research, and where applicable suggests topics of critical importance to various countries/regions.